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Epha5 Gene Detail
Summary
  • Symbol
    Epha5
  • Name
    Eph receptor A5
  • Synonyms
    bsk, Cek7, Ehk1, Els1, Hek7, Rek7
  • Feature Type
    protein coding gene
  • IDs
    MGI:99654
    NCBI Gene: 13839
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:84202620-84565241 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.00 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9072 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99654
 protein coding gene Chr5:84199024-84565677 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029662
 protein coding gene Chr5:84754573-85166745 (-)
A/J MGP_AJ_G0029630
 protein coding gene Chr5:81333022-81695945 (-)
AKR/J MGP_AKRJ_G0029578
 protein coding gene Chr5:84039750-84402527 (-)
BALB/cJ MGP_BALBcJ_G0029639
 protein coding gene Chr5:82200711-82576418 (-)
C3H/HeJ MGP_C3HHeJ_G0029362
 protein coding gene Chr5:84498554-84879528 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030093
 protein coding gene Chr5:88174673-88593390 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027335
 protein coding gene Chr5:77311604-77680069 (-)
CAST/EiJ MGP_CASTEiJ_G0028770
 protein coding gene Chr5:83750613-84153014 (-)
CBA/J MGP_CBAJ_G0029331
 protein coding gene Chr5:91042319-91475424 (-)
DBA/2J MGP_DBA2J_G0029476
 protein coding gene Chr5:81446817-81812580 (-)
FVB/NJ MGP_FVBNJ_G0029437
 protein coding gene Chr5:80494846-80859267 (-)
LP/J MGP_LPJ_G0029563
 protein coding gene Chr5:85188114-85575760 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029465
 protein coding gene Chr5:95397746-95957832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030126
 protein coding gene Chr5:83614410-83990235 (-)
PWK/PhJ MGP_PWKPhJ_G0028494
 protein coding gene Chr5:80488598-80857024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028328
 protein coding gene Chr5:82955095-83354510 (-)
WSB/EiJ MGP_WSBEiJ_G0028851
 protein coding gene Chr5:83953403-84343583 (-)



Homology
more
  • Human Ortholog
    EPHA5, EPH receptor A5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA5, EPH receptor A5
  • Synonyms
    CEK7, EHK1, EHK-1, EK7, HEK7, TYRO4
  • Links
    NCBI Gene ID: 2044
    neXtProt AC: NX_P54756
    UniProt: P54756

  • Chr Location
    4q13.1-q13.2; chr4:65319563-65670495 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are overtly normal but show abnormal retinal axon mapping.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1743
  • Tissues
    533
  • cDNA Data
    14
  • Literature Summary
    67
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029245 Ensembl Gene Model | MGI Sequence Detail 362622 C57BL/6J ±  kb
transcript ENSMUST00000113403 Ensembl | MGI Sequence Detail 4675 Not Applicable  
polypeptide ENSMUSP00000109030 Ensembl | MGI Sequence Detail 1040 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000007125 ephrin type-A receptor 5
    (term hierarchy)
  • PDB
    5ZRZ
  • EC
    2.7.10.1
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR008979 Galactose-binding-like domain superfamily
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
  • GlyGen
    Q60629 3 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 36
    Genomic 2
    cDNA 18
    Primer pair 7
    Other 9

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-16439, MGD-MRK-19365, MGD-MRK-9361, MGI:2141004, MGI:2141160, MGI:95318
References
more
  • Summaries
    All 132
    Developmental Gene Expression 67
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory