About   Help   FAQ
Epha5 Gene Detail
Summary
  • Symbol
    Epha5
  • Name
    Eph receptor A5
  • Synonyms
    bsk, Cek7, Ehk1, Els1, Hek7, Rek7
  • Feature Type
    protein coding gene
  • IDs
    MGI:99654
    NCBI Gene: 13839
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:84202620-84565241 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.00 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9072 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99654
 protein coding gene Chr5:84199024-84565677 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029662
 protein coding gene Chr5:84754573-85166745 (-)
A/J MGP_AJ_G0029630
 protein coding gene Chr5:81333022-81695945 (-)
AKR/J MGP_AKRJ_G0029578
 protein coding gene Chr5:84039750-84402527 (-)
BALB/cJ MGP_BALBcJ_G0029639
 protein coding gene Chr5:82200711-82576418 (-)
C3H/HeJ MGP_C3HHeJ_G0029362
 protein coding gene Chr5:84498554-84879528 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030093
 protein coding gene Chr5:88174673-88593390 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027335
 protein coding gene Chr5:77311604-77680069 (-)
CAST/EiJ MGP_CASTEiJ_G0028770
 protein coding gene Chr5:83750613-84153014 (-)
CBA/J MGP_CBAJ_G0029331
 protein coding gene Chr5:91042319-91475424 (-)
DBA/2J MGP_DBA2J_G0029476
 protein coding gene Chr5:81446817-81812580 (-)
FVB/NJ MGP_FVBNJ_G0029437
 protein coding gene Chr5:80494846-80859267 (-)
LP/J MGP_LPJ_G0029563
 protein coding gene Chr5:85188114-85575760 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029465
 protein coding gene Chr5:95397746-95957832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030126
 protein coding gene Chr5:83614410-83990235 (-)
PWK/PhJ MGP_PWKPhJ_G0028494
 protein coding gene Chr5:80488598-80857024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028328
 protein coding gene Chr5:82955095-83354510 (-)
WSB/EiJ MGP_WSBEiJ_G0028851
 protein coding gene Chr5:83953403-84343583 (-)



Homology
more
  • Human Ortholog
    EPHA5, EPH receptor A5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA5, EPH receptor A5
  • Synonyms
    CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
  • Links
    NCBI Gene ID: 2044
    UniProt: P54756

  • Chr Location
    4q13.1-q13.2; chr4:65319563-65670495 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are overtly normal but show abnormal retinal axon mapping.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1764
  • Tissues
    544
  • cDNA Data
    16
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029245 Ensembl Gene Model | MGI Sequence Detail 362622 C57BL/6J ±  kb
    transcript ENSMUST00000113403 Ensembl | MGI Sequence Detail 4675 Not Applicable  
    polypeptide ENSMUSP00000109030 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000007125 ephrin type-A receptor 5
      (term hierarchy)
    • PDB
      5ZRZ
    • EC
      2.7.10.1
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      Q60629 5 sites, 4 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 2
      cDNA 21
      Primer pair 8
      Other 12
      Antibodies 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16439, MGD-MRK-19365, MGD-MRK-9361, MGI:2141004, MGI:2141160, MGI:95318
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 71
      Gene Ontology 15
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358820 Dudukcu O, et al., Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain. iScience. 2024 Nov 15;27(11):111239
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    01/20/2026
    MGI 6.24     		The Jackson Laboratory