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Pde4d Gene Detail
Summary
  • Symbol
    Pde4d
  • Name
    phosphodiesterase 4D, cAMP specific
  • Synonyms
    9630011N22Rik, Dpde3, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99555
    NCBI Gene: 238871
  • Alliance
    genome feature page
  • Transcription Start Sites
    40 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:108790711-110092503 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 59.69 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37780 from dbSNP Build 142
  • Strain Annotations
    24
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99555
 protein coding gene Chr13:108586482-110092503 (+)
129S1/SvImJ ENSMUSG00200030023
 protein coding gene Chr13:104521149-104547466 (+)
129S1/SvImJ ENSMUSGG00200054834
 protein coding gene Chr13:104499190-104499777 (+)
A/J ENSMUSGG00195055278
 protein coding gene Chr13:105027082-105027669 (+)
A/J ENSMUSG00195012941
 protein coding gene Chr13:105049041-105080509 (+)
AKR/J ENSMUSGG00220054521
 protein coding gene Chr13:103454280-103454867 (+)
AKR/J ENSMUSG00220029716
 protein coding gene Chr13:103476338-103508832 (+)
BALB/cJ ENSMUSG00180028002
 protein coding gene Chr13:105620427-105651895 (+)
BALB/cJ ENSMUSGG00180055407
 protein coding gene Chr13:105598472-105599059 (+)
C3H/HeJ ENSMUSG00175025932
 protein coding gene Chr13:105713552-105740899 (+)
C3H/HeJ ENSMUSGG00175054882
 protein coding gene Chr13:105691496-105692083 (+)
C57BL/6NJ ENSMUSG00215021575
 protein coding gene Chr13:105719144-105750603 (+)
C57BL/6NJ ENSMUSGG00215055540
 protein coding gene Chr13:105697183-105697770 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018881
 protein coding gene Chr13:101862598-103291495 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054616
 protein coding gene Chr13:105018828-105019415 (+)
CBA/J ENSMUSG00210010469
 protein coding gene Chr13:105040884-105073373 (+)
DBA/2J ENSMUSG00185025963
 protein coding gene Chr13:108796813-108829306 (+)
DBA/2J ENSMUSGG00185057843
 protein coding gene Chr13:108774757-108775344 (+)
FVB/NJ ENSMUSGG00205054616
 protein coding gene Chr13:104455742-104456329 (+)
FVB/NJ ENSMUSG00205006666
 protein coding gene Chr13:104477701-104509170 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230006135
 protein coding gene Chr13:117503357-119020397 (+)
NOD/ShiLtJ ENSMUSG00190018839
 protein coding gene Chr13:105351171-105383256 (+)
NOD/ShiLtJ ENSMUSGG00190054722
 protein coding gene Chr13:105329151-105329738 (+)
NZO/HlLtJ ENSMUSG00225036701
 protein coding gene Chr13:110741495-111246018 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PDE4D, phosphodiesterase 4D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4D, phosphodiesterase 4D
  • Synonyms
    ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
  • Links
    NCBI Gene ID: 5144
    UniProt: Q08499

  • Chr Location
    5q11.2-q12.1; chr5:58969038-60522128 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human PDE4D associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    138
  • cDNA Data
    21
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238871 NCBI Gene Model | MGI Sequence Detail 1301793 C57BL/6J ±  kb
    transcript NM_001402885 RefSeq | MGI Sequence Detail 7863 C57BL/6  
    polypeptide Q01063 UniProt | EBI | MGI Sequence Detail 747 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      20 Sequences
    • Protein Ontology
      PR:000012475 3',5'-cyclic-AMP phosphodiesterase 4D
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.53
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
      IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
    • GlyGen
      Q01063 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 23
      Primer pair 4
      Other 3
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16333, MGI:2145249, MGI:2444663
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 10
      Gene Ontology 18
      Phenotypes 39
    • Earliest
      J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
    • Latest
      J:386189 Zhao W, et al., PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior. FASEB J. 2025 Aug 15;39(15):e70882
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory