Hspa1b MGI Mouse Gene Detail - MGI:99517 - heat shock protein family A (Hsp70) member 1B

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Hspa1b Gene Detail

Symbol

Hspa1b
Name

heat shock protein family A (Hsp70) member 1B
Synonyms

hsp68, Hsp70-1, Hsp70.1, HSP70B1

Feature Type

protein coding gene
IDs

MGI:99517
NCBI Gene: 15511
Alliance

genome feature page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr17:35175412-35178214 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.50 cM
Mapping Data

18 experiments

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Strain Annotations

19
PCR

4
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_99517	protein coding gene	Chr17:35175405-35178214 (-)
129S1/SvImJ	ENSMUSG00200049209	protein coding gene	Chr17:30879521-30882323 (-)
A/J	ENSMUSG00195041592	protein coding gene	Chr17:31779677-31782475 (-)
AKR/J	ENSMUSG00220050048	protein coding gene	Chr17:30808370-30811168 (-)
BALB/cJ	ENSMUSG00180039778	protein coding gene	Chr17:31149552-31152350 (-)
C3H/HeJ	ENSMUSG00175034721	protein coding gene	Chr17:30694483-30697281 (-)
C57BL/6NJ	ENSMUSG00215051473	protein coding gene	Chr17:30719718-30722522 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021486	protein coding gene	Chr17:31698032-31700884 (-)
CAST/EiJ	ENSTCUG00005048742	protein coding gene	Chr17:31738062-31740860 (-)
CBA/J	ENSMUSG00210047052	protein coding gene	Chr17:30516591-30519391 (-)
DBA/2J	ENSMUSG00185051242	protein coding gene	Chr17:33168791-33171589 (-)
FVB/NJ	ENSMUSG00205029996	protein coding gene	Chr17:31038190-31040960 (-)
JF1/MsJ	ENSUMUG00000056952	protein coding gene	Chr17:32421669-32424464 (-)
LP/J	ENSMUSG00230054598	protein coding gene	Chr17:34277782-34280584 (-)
NOD/ShiLtJ	ENSMUSG00190052631	protein coding gene	Chr17:30639092-30641878 (-)
NZO/HlLtJ	ENSMUSG00225054780	protein coding gene	Chr17:36290757-36293547 (-)
PWK/PhJ	ENSLUMG00010039345	protein coding gene	Chr17:30256157-30258955 (-)
SPRET/EiJ	ENSMSPG00010033094	protein coding gene	Chr17:31455182-31458146 (-)
WSB/EiJ	ENSIUOG00005042790	protein coding gene	Chr17:31366715-31369507 (-)

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Human Ortholog

HSPA1B, heat shock protein family A (Hsp70) member 1B

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA1B, heat shock protein family A (Hsp70) member 1B
Synonyms

HSP70-1, HSP70.1, HSP70-1B, HSP70-2, HSP70.2, HSP72, HSPA1, HSX70
Links

HGNC:5233

NCBI Gene ID: 3304

UniProt: P0DMV9
Chr Location

6p21.33; chr6:31827738-31830254 (+) GRCh38

MGI Vertebrate Homology

Hspa1b stringent orthology
1 human;1 mouse;2 rat;4 zebrafish
HCOP

vertebrate homology predictions: HSPA1B
Gene Tree

Hspa1b

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Diseases

14 with human HSPA1B associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				aspirin-induced respiratory disease IDs aspirin-induced respiratory disease DOID:0080822
				congenital anomalies of the kidney and urinary tract IDs congenital anomalies of the kidney and urinary tract DOID:0080205 MESH:C566906 OMIM:PS610805 ORDO:93545
				idiopathic pulmonary fibrosis IDs idiopathic pulmonary fibrosis DOID:0050156 EFO:0000768 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35716 UMLS_CUI:C1800706
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				lung small cell carcinoma IDs lung small cell carcinoma DOID:5409 KEGG:05222 MESH:D055752 NCI:C4917 OMIM:182280 UMLS_CUI:C0149925
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				pneumoconiosis IDs pneumoconiosis DOID:10316 ICD10CM:J64 ICD9CM:505 MESH:D011009 NCI:C26861 UMLS_CUI:C0032273
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				senile cataract IDs senile cataract DOID:9669 ICD10CM:H25 ICD9CM:366.1 ICD9CM:366.10 NCI:C35012 UMLS_CUI:C0036646
				stroke IDs stroke DOID:0051061
				toxic shock syndrome IDs toxic shock syndrome DOID:14115 ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 UMLS_CUI:C0600327
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary tract infection IDs urinary tract infection DOID:0080784 ICD10CM:N39.0 MESH:D014552

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 5 alleles in 5 genetic backgrounds
70 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Targeted

6
Genomic Mutations

1 involving Hspa1b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results in increased susceptibility to focal cerebral ischemic injury.

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All GO Annotations

83
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

660
Tissues

30
cDNA Data

8
Literature Summary

24

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa1b

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS37592.1

Ensembl

ENSMUSG00000090877 (Evidence)
NCBI Gene

15511

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000090877	Ensembl Gene Model \| MGI Sequence Detail	2803	C57BL/6J	± kb
	transcript	ENSMUST00000172753	Ensembl \| MGI Sequence Detail	2803	Not Applicable
	polypeptide	ENSMUSP00000133815	Ensembl \| MGI Sequence Detail	642	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000024839 heat shock 70 kDa protein 1B

(term hierarchy)
GlyGen

P17879 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 33

Genomic 17

cDNA 10

Primer pair 5

Other 1

Antibodies 7

Microarray probesets 4

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MGD-MRK-10958, MGD-MRK-16294

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Summaries

All 291

Developmental Gene Expression 24

Gene Ontology 18

Phenotypes 70
Earliest

J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
Latest

J:377026 Deng Q, et al., N-terminal alpha-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis. Nat Commun. 2025 Nov 27;16(1):11687

TSS for Hspa1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147702	Chr17:35178560-35178568 (-)	-350 bp
Tssr147701	Chr17:35178208-35178214 (-)	3 bp
Tssr147700	Chr17:35178089-35178126 (-)	106 bp
Tssr147699	Chr17:35176099-35176123 (-)	2,103 bp
Tssr147698	Chr17:35175795-35175804 (-)	2,414 bp

Hspa1b is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs5	Chr17, syntenic		J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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