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Xist Gene Detail
Summary
  • Symbol
    Xist
  • Name
    inactive X specific transcripts
  • Feature Type
    lncRNA gene
  • IDs
    MGI:98974
    NCBI Gene: 213742
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:102503979-102526839 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.15 cM, cytoband D
  • Mapping Data
    62 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98974
lncRNA gene ChrX:102503972-102526860 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007554
lincRNA gene ChrX:100105215-100129148 (-)
A/J MGP_AJ_G0007553
lincRNA gene ChrX:100040721-100062978 (-)
AKR/J MGP_AKRJ_G0007523
lincRNA gene ChrX:103058913-103083554 (-)
BALB/cJ MGP_BALBcJ_G0007527
lincRNA gene ChrX:98838174-98860947 (-)
C3H/HeJ MGP_C3HHeJ_G0007474
lincRNA gene ChrX:100568330-100592165 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007700
lincRNA gene ChrX:103072506-103094731 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006877
lincRNA gene ChrX:97682958-97704771 (-)
CAST/EiJ MGP_CASTEiJ_G0007376
lincRNA gene ChrX:84843440-84867656 (-)
CBA/J MGP_CBAJ_G0007455
lincRNA gene ChrX:106258542-106280546 (-)
DBA/2J MGP_DBA2J_G0007480
lincRNA gene ChrX:99285277-99308100 (-)
FVB/NJ MGP_FVBNJ_G0007496
lincRNA gene ChrX:98589955-98612146 (-)
LP/J MGP_LPJ_G0007560
lincRNA gene ChrX:101123703-101149086 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007476
lincRNA gene ChrX:110912285-110935792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007703
lincRNA gene ChrX:99796259-99818199 (-)
PWK/PhJ MGP_PWKPhJ_G0007314
lincRNA gene ChrX:82421835-82445404 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007218
lincRNA gene ChrX:85543143-85567986 (-)
WSB/EiJ MGP_WSBEiJ_G0007437
lincRNA gene ChrX:98516010-98541875 (-)



Homology
more
  • Human Ortholog
    XIST, X inactive specific transcript
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XIST, X inactive specific transcript
  • Synonyms
    DXS1089, DXS399E, LINC00001, NCRNA00001, swd66, SXI1
  • Links
    NCBI Gene ID: 7503

  • Chr Location
    Xq13.2; chrX:73820649-73852753 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 16 alleles in 8 genetic backgrounds
    32 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Xist function in X-inactivation is disrupted in females carrying a null mutation. Depending on maternal or paternal derivation of the mutation, females survive or die in early embryogenesis. In either case, X-inactivation is non-random and abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213742 NCBI Gene Model | MGI Sequence Detail 22861 C57BL/6J ±  kb
    transcript NR_001463 RefSeq | MGI Sequence Detail 17918 Not Specified  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 94
      cDNA 36
      Primer pair 18
      Other 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15474, MGI:2147863
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 79
      Gene Ontology 10
      Phenotypes 58
    • Earliest
      J:2970 Brown SD, XIST and the mapping of the X chromosome inactivation centre. Bioessays. 1991 Nov;13(11):607-12
    • Latest
      J:339367 Masui O, et al., Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages. Nat Cell Biol. 2023 Jan;25(1):134-144

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory