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Zrsr2-ps1 Pseudogene Detail
Summary
  • Symbol
    Zrsr2-ps1
  • Name
    zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1
  • Synonyms
    35kDa, D11Ncvs75, Irlgs2, SP2, U2af1-rs1, U2afbp-rs, Zrsr1
Location &
Maps
more
  • Sequence Map
    Chr11:22922019-22926500 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 14.24 cM, cytoband A3-4
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98885
 pseudogene Chr11:22922019-22926500 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Synonyms
    OFD21, U2AF1L2, U2AF1-RS2, U2AF1RS2, URP, ZC3H22
  • Links
    NCBI Gene ID: 8233
    UniProt: Q15696

  • Chr Location
    Xp22.2; chrX:15790106-15830694 (+)  GRCh38
  • Human Ortholog
    ZRSR2P1, ZRSR2 pseudogene 1
  • Synonyms
    U2AF1L1, U2AF1P, U2AF1-RS1, U2AF1RS1, U2AFBPL, ZC3H21, ZRSR1
  • Links
    NCBI Gene ID: 7310
    UniProt: Q15695

  • Chr Location
    5q22.2; chr5:112891610-112893097 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ZRSR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Zrsr2-ps1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    13 strains or lines available
Heterozygotes for a targeted null mutation of this imprinted gene are viable and fertile regardless of the parental origin of the mutated allele. Mice inheriting a null allele maternally and a paternal null allele for Zrsr1 fail to develop beyond the 2 cell stage, with very few reaching morula stage and none implanting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    89
  • Tissues
    42
  • cDNA Data
    34
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22183 NCBI Gene Model | MGI Sequence Detail 4482 C57BL/6J ±  kb
transcript NR_175920 RefSeq | MGI Sequence Detail 4482 ZRU/MplStud  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 12
    cDNA 36
    Primer pair 10
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11468, MGD-MRK-15322, MGD-MRK-3013, MGI:7430927
References
more
  • Summaries
    All 63
    Developmental Gene Expression 15
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:390083 Fu Y, et al., Disrupted minor intron splicing activates reductive carboxylation-mediated lipogenesis to drive metabolic dysfunction-associated steatotic liver disease progression. J Clin Invest. 2025 May 15;135(10)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory