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Tal1 Gene Detail
Summary
  • Symbol
    Tal1
  • Name
    T cell acute lymphocytic leukemia 1
  • Synonyms
    bHLHa17, Hpt, Scl, SCL/tal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98480
    NCBI Gene: 21349
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:114913623-114928952 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 52.73 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98480
 protein coding gene Chr4:114913623-114928952 (+)
129S1/SvImJ ENSMUSG00200045128
 protein coding gene Chr4:108796170-108811492 (+)
A/J ENSMUSG00195043378
 protein coding gene Chr4:110129172-110144462 (+)
AKR/J ENSMUSG00220012253
 protein coding gene Chr4:109399470-109414791 (+)
BALB/cJ ENSMUSG00180044947
 protein coding gene Chr4:108142358-108157673 (+)
C3H/HeJ ENSMUSG00175031314
 protein coding gene Chr4:109156859-109172172 (+)
C57BL/6NJ ENSMUSG00215032166
 protein coding gene Chr4:110284051-110299385 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026304
 protein coding gene Chr4:105500959-105515901 (+)
CAST/EiJ ENSTCUG00005021731
 protein coding gene Chr4:108934123-108949409 (+)
CBA/J ENSMUSG00210052965
 protein coding gene Chr4:108770416-108785724 (+)
DBA/2J ENSMUSG00185048242
 protein coding gene Chr4:110292594-110307880 (+)
FVB/NJ ENSMUSG00205028738
 protein coding gene Chr4:108342039-108357359 (+)
JF1/MsJ ENSUMUG00000019640
 protein coding gene Chr4:110244261-110259555 (+)
LP/J ENSMUSG00230043886
 protein coding gene Chr4:113613550-113628872 (+)
NOD/ShiLtJ ENSMUSG00190031871
 protein coding gene Chr4:108139821-108155133 (+)
NZO/HlLtJ ENSMUSG00225009280
 protein coding gene Chr4:119100971-119116290 (+)
PWK/PhJ ENSLUMG00010040857
 protein coding gene Chr4:107638541-107653849 (+)
SPRET/EiJ ENSMSPG00010022401
 protein coding gene Chr4:109787971-109800929 (+)
WSB/EiJ ENSIUOG00005035476
 protein coding gene Chr4:108453042-108468373 (+)



Homology
more
  • Human Ortholog
    TAL1, TAL bHLH transcription factor 1, erythroid differentiation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAL1, TAL bHLH transcription factor 1, erythroid differentiation factor
  • Synonyms
    bHLHa17, SCL, tal-1, TCL5
  • Links
    NCBI Gene ID: 6886
    UniProt: P17542

  • Chr Location
    1p33; chr1:47216290-47232335 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tal1 mouse models; 1 with human TAL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 10 alleles in 10 genetic backgrounds
    2 images
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1170
  • Tissues
    321
  • cDNA Data
    35
  • Literature Summary
    103
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21349 NCBI Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
    transcript NM_001425784 RefSeq | MGI Sequence Detail 4649 C57BL/6  
    polypeptide P22091 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016043 T-cell acute lymphocytic leukemia protein 1
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR040238 Helix-loop-helix protein TAL-like
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 3
      cDNA 35
      Primer pair 19
      Other 7
      Antibodies 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219
    References
    more
    • Summaries
      All 310
      Developmental Gene Expression 103
      Diseases 1
      Gene Ontology 47
      Phenotypes 75
    • Earliest
      J:8017 Blackwell JM, et al., Response of BALB/c mice to leishmanial infection. Curr Top Microbiol Immunol. 1985;122:97-106
    • Latest
      J:379645 Kilpinen S, et al., Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem. Elife. 2025 Sep 12;14
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory