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Serpina3m Gene Detail
Summary
  • Symbol
    Serpina3m
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3M
  • Synonyms
    3e46, alpha-1 antiproteinase, antitrypsin, contrapsin-like, MMCM7, MMSPi2.4, Spi2.4, Spi-2l, Spi2-rs1, Spi-2rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98378
    NCBI Gene: 20717
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104353424-104360518 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 54.12 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98378
 protein coding gene Chr12:104304745-104360518 (+)
129S1/SvImJ ENSMUSG00200023945
 protein coding gene Chr12:96042300-96124089 (+)
A/J ENSMUSG00195020299
 protein coding gene Chr12:98632350-98688136 (+)
AKR/J ENSMUSG00220037925
 protein coding gene Chr12:96520295-96557219 (+)
BALB/cJ ENSMUSG00180035748
 protein coding gene Chr12:97853983-97868086 (+)
C3H/HeJ ENSMUSG00175032697
 protein coding gene Chr12:100444529-100500298 (+)
C57BL/6NJ ENSMUSG00215040330
 protein coding gene Chr12:97106434-97162211 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018074
 protein coding gene Chr12:98860602-98867373 (+)
CAST/EiJ ENSTCUG00005018647
 protein coding gene Chr12:96546320-96603976 (+)
CBA/J ENSMUSG00210014317
 protein coding gene Chr12:97545926-97560023 (+)
DBA/2J ENSMUSG00185044833
 protein coding gene Chr12:99312006-99326109 (+)
FVB/NJ ENSMUSG00205016249
 protein coding gene Chr12:96465660-96547460 (+)
JF1/MsJ ENSUMUG00000021930
 protein coding gene Chr12:103999761-104063527 (+)
LP/J ENSMUSGG00230055441
 protein coding gene Chr12:106382324-106389581 (+)
NOD/ShiLtJ ENSMUSG00190021766
 protein coding gene Chr12:88652859-88666962 (-)
NZO/HlLtJ ENSMUSG00225036664
 protein coding gene Chr12:108071072-108126857 (+)
PWK/PhJ ENSLUMG00010013230
 protein coding gene Chr12:97442179-97504356 (+)
SPRET/EiJ ENSMSPG00010016823
 protein coding gene Chr12:99791548-99886276 (+)
WSB/EiJ ENSIUOG00005008464
 protein coding gene Chr12:96556830-96570933 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612377-94624645 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SERPINA3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    7
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20717 NCBI Gene Model | MGI Sequence Detail 7095 C57BL/6J ±  kb
transcript NM_009253 RefSeq | MGI Sequence Detail 1660 C57BL/6  
polypeptide Q03734 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14522, MGD-MRK-14524, MGD-MRK-14527, MGI:2144772
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:11249 Ohkubo K, et al., Cloning, structure and expression of cDNA for mouse contrapsin and a related protein. Biochem J. 1991 Jun 1;276(Pt 2):337-42
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory