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Rfc1 Gene Detail
Summary
  • Symbol
    Rfc1
  • Name
    replication factor C (activator 1) 1
  • Synonyms
    140kDa, Alp145, Recc1, RFC140
  • Feature Type
    protein coding gene
  • IDs
    MGI:97891
    NCBI Gene: 19687
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65419195-65492988 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.61 cM, cytoband C
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1966 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97891
 protein coding gene Chr5:65419193-65493013 (-)
129S1/SvImJ ENSMUSG00200034390
 protein coding gene Chr5:61036583-61110414 (-)
A/J ENSMUSG00195000231
 protein coding gene Chr5:60406929-60480721 (-)
AKR/J ENSMUSG00220007004
 protein coding gene Chr5:60548605-60622440 (-)
BALB/cJ ENSMUSG00180005841
 protein coding gene Chr5:60192758-60266553 (-)
C3H/HeJ ENSMUSG00175025126
 protein coding gene Chr5:62227127-62300878 (-)
C57BL/6NJ ENSMUSG00215005190
 protein coding gene Chr5:60965452-61039279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027245
 protein coding gene Chr5:58544343-58626327 (-)
CAST/EiJ ENSTCUG00005000227
 protein coding gene Chr5:60115936-60189417 (-)
CBA/J ENSMUSG00210022961
 protein coding gene Chr5:61140087-61213841 (-)
DBA/2J ENSMUSG00185005267
 protein coding gene Chr5:62997604-63071351 (-)
FVB/NJ ENSMUSG00205010414
 protein coding gene Chr5:59949325-60023152 (-)
JF1/MsJ ENSUMUG00000017143
 protein coding gene Chr5:67449161-67542115 (-)
LP/J ENSMUSG00230006081
 protein coding gene Chr5:67649350-67723172 (-)
NOD/ShiLtJ ENSMUSG00190000250
 protein coding gene Chr5:60132012-60205796 (-)
NZO/HlLtJ ENSMUSG00225009881
 protein coding gene Chr5:72775394-72849241 (-)
PWK/PhJ ENSLUMG00010004070
 protein coding gene Chr5:60075143-60149418 (-)
SPRET/EiJ ENSMSPG00010032317
 protein coding gene Chr5:61897361-61970654 (-)
WSB/EiJ ENSIUOG00005016422
 protein coding gene Chr5:63088698-63162406 (-)



Homology
more
  • Human Ortholog
    RFC1, replication factor C subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFC1, replication factor C subunit 1
  • Synonyms
    A1, CANVAS, MHCBFB, PO-GA, RECC1, RFC, RFC140
  • Links
    NCBI Gene ID: 5981
    UniProt: P35251

  • Chr Location
    4p14; chr4:39287456-39366395 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human RFC1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    86
  • cDNA Data
    184
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19687 NCBI Gene Model | MGI Sequence Detail 73794 C57BL/6J ±  kb
    transcript NM_001421209 RefSeq | MGI Sequence Detail 4768 ZRU/MplStud  
    polypeptide P35601 UniProt | EBI | MGI Sequence Detail 1131 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 189
      cDNA 188
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13825
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory