About   Help   FAQ
Eprs1 Gene Detail
Summary
  • Symbol
    Eprs1
  • Name
    glutamyl-prolyl-tRNA synthetase 1
  • Synonyms
    2410081F06Rik, 3010002K18Rik, Eprs, Qprs
  • Feature Type
    protein coding gene
  • IDs
    MGI:97838
    NCBI Gene: 107508
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185095241-185160557 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.50 cM, cytoband H4-H6
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1868 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97838
 protein coding gene Chr1:185093614-185160557 (+)
129S1/SvImJ ENSMUSG00200021558
 protein coding gene Chr1:182873860-182940257 (+)
A/J ENSMUSG00195041394
 protein coding gene Chr1:182460095-182525815 (+)
AKR/J ENSMUSG00220019399
 protein coding gene Chr1:181682578-181749024 (+)
BALB/cJ ENSMUSG00180032739
 protein coding gene Chr1:182526305-182592028 (+)
C3H/HeJ ENSMUSG00175033537
 protein coding gene Chr1:182701805-182767524 (+)
C57BL/6NJ ENSMUSG00215023450
 protein coding gene Chr1:181911195-181977356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015023
 protein coding gene Chr1:175224313-175292923 (+)
CAST/EiJ ENSTCUG00005042924
 protein coding gene Chr1:180469238-180535373 (+)
CBA/J ENSMUSG00210018678
 protein coding gene Chr1:182361201-182427359 (+)
DBA/2J ENSMUSG00185035147
 protein coding gene Chr1:186975867-187042030 (+)
FVB/NJ ENSMUSG00205033407
 protein coding gene Chr1:181394404-181460126 (+)
JF1/MsJ ENSUMUG00000003163
 protein coding gene Chr1:185975392-186041720 (+)
LP/J ENSMUSG00230021877
 protein coding gene Chr1:186535947-186602358 (+)
NOD/ShiLtJ ENSMUSG00190029508
 protein coding gene Chr1:182376008-182441719 (+)
NZO/HlLtJ ENSMUSG00225010441
 protein coding gene Chr1:190269784-190335948 (+)
PWK/PhJ ENSLUMG00010015096
 protein coding gene Chr1:181224047-181289757 (+)
SPRET/EiJ ENSMSPG00010021795
 protein coding gene Chr1:184724616-184790441 (+)
WSB/EiJ ENSIUOG00005010370
 protein coding gene Chr1:181569593-181635293 (+)



Homology
more
  • Human Ortholog
    EPRS1, glutamyl-prolyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPRS1, glutamyl-prolyl-tRNA synthetase 1
  • Synonyms
    EARS, EPRS, GLUPRORS, HLD15, PARS, PIG32, QARS, QPRS
  • Links
    NCBI Gene ID: 2058
    UniProt: P07814

  • Chr Location
    1q41; chr1:219968598-220046616 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EPRS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a phospho-mimetic allele exhibit normal body weight, life span and glucose metabolism. Mice homozygous for a phospho-deficient allele exhibit decreased body weight, enhanced lipolysis, altered glucose metabolism and increased energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    102
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026615 Ensembl Gene Model | MGI Sequence Detail 65317 C57BL/6J ±  kb
    transcript ENSMUST00000046514 Ensembl | MGI Sequence Detail 4906 Not Applicable  
    polypeptide ENSMUSP00000045841 Ensembl | MGI Sequence Detail 1512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000007144 bifunctional glutamate/proline--tRNA ligase
      (term hierarchy)
    • EC
      6.1.1.15, 6.1.1.17
    • InterPro Domains
      IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
      IPR004154 Anticodon-binding
      IPR036621 Anticodon-binding domain superfamily
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR042450 Eukaryotic translation elongation factor 1 epsilon-1
      IPR050132 Glutamine/Glutamate--tRNA Ligase
      IPR000924 Glutamyl/glutaminyl-tRNA synthetase
      IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
      IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
      IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR011035 Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
      IPR020056 Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal
      IPR053836 Nuclear-export cofactor Arc1-like, N-terminal domain
      IPR004499 Proline-tRNA ligase, class IIa, archaeal-type
      IPR016061 Proline-tRNA ligase, class II, C-terminal
      IPR033721 Prolyl-tRNA synthetase, catalytic domain
      IPR017449 Prolyl-tRNA synthetase, class II
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
      IPR049437 tRNA synthetases class I (E and Q), anti-codon binding domain
      IPR009068 uS15/NS1, RNA-binding domain superfamily
      IPR000738 WHEP-TRS domain
    • GlyGen
      Q8CGC7 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 33
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-13739, MGI:1919640, MGI:1924024, MGI:2138682, MGI:7484189
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:16735 Kaiser E, et al., The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. Genomics. 1994 Jan 15;19(2):280-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory