Ptger2 MGI Mouse Gene Detail - MGI:97794 - prostaglandin E receptor 2 (subtype EP2)

Symbol

Ptger2
Name

prostaglandin E receptor 2 (subtype EP2)
Synonyms

EP2, EP2 receptor, Ptgerep2

Feature Type

protein coding gene
IDs

MGI:97794
NCBI Gene: 19217
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:45225652-45241277 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 22.68 cM
Mapping Data

1 experiment

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97794	protein coding gene	Chr14:45225568-45241277 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021203	protein coding gene	Chr14:38592926-38615369 (+)
A/J	MGP_AJ_G0021149	protein coding gene	Chr14:37435750-37451408 (+)
AKR/J	MGP_AKRJ_G0021127	protein coding gene	Chr14:38935579-38955267 (+)
BALB/cJ	MGP_BALBcJ_G0021153	protein coding gene	Chr14:37493869-37512082 (+)
C3H/HeJ	MGP_C3HHeJ_G0020936	protein coding gene	Chr14:38732445-38749696 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021587	protein coding gene	Chr14:40268718-40285477 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019146	protein coding gene	Chr14:36889066-36904671 (+)
CAST/EiJ	MGP_CASTEiJ_G0020461	protein coding gene	Chr14:35840656-35864540 (+)
CBA/J	MGP_CBAJ_G0020902	protein coding gene	Chr14:41544145-41574365 (+)
DBA/2J	MGP_DBA2J_G0021025	protein coding gene	Chr14:37375613-37393966 (+)
FVB/NJ	MGP_FVBNJ_G0021009	protein coding gene	Chr14:37133510-37150425 (+)
LP/J	MGP_LPJ_G0021095	protein coding gene	Chr14:38899161-38913840 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021035	protein coding gene	Chr14:40950304-40967786 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021620	protein coding gene	Chr14:38475368-38492304 (+)
PWK/PhJ	MGP_PWKPhJ_G0020210	protein coding gene	Chr14:34238254-34255011 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020032	protein coding gene	Chr14:34601890-34618382 (+)
WSB/EiJ	MGP_WSBEiJ_G0020517	protein coding gene	Chr14:38569716-38588502 (+)

Human Ortholog

PTGER2, prostaglandin E receptor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTGER2, prostaglandin E receptor 2
Synonyms

EP2
Links

HGNC:9594

NCBI Gene ID: 5732

neXtProt AC: NX_P43116

UniProt: P43116
Chr Location

14q22.1; chr14:52314305-52328598 (+) GRCh38

MGI Vertebrate Homology

Ptger2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTGER2
Gene Tree

Ptger2

Diseases

1 with human PTGER2 associations

				Human Disease	Mouse Models
				asthma, nasal polyps, and aspirin intolerance IDs asthma, nasal polyps, and aspirin intolerance DOID:0111579 MESH:C565935 OMIM:208550

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

38 phenotypes from 6 alleles in 12 genetic backgrounds
8 phenotypes from multigenic genotypes
131 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

11
Genomic Mutations

1 involving Ptger2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for one targeted null mutation exhibit increased blood pressure when fed a high-salt diet. Female mutants for 2 null alleles have small litters due to impaired ovulation.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

63
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptger2

ZFIN ptger2a, ptger2b

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS26972.1

Ensembl

ENSMUSG00000037759 (Evidence)
NCBI Gene

19217

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037759	Ensembl Gene Model \| MGI Sequence Detail	15626	C57BL/6J	± kb
transcript	ENSMUST00000046891	Ensembl \| MGI Sequence Detail	3684	Not Applicable
polypeptide	ENSMUSP00000038483	Ensembl \| MGI Sequence Detail	362	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001658 prostaglandin E2 receptor EP2 subtype

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001923 Prostanoid EP2 receptor

IPR008365 Prostanoid receptor

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All nucleic 21

cDNA 18

Primer pair 3

Microarray probesets 3

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MGD-MRK-13661

Summaries

All 193

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 131
Earliest

J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
Latest

J:346107 Meiser P, et al., A distinct stimulatory cDC1 subpopulation amplifies CD8(+) T cell responses in tumors for protective anti-cancer immunity. Cancer Cell. 2023 Aug 14;41(8):1498-1515.e10

TSS for Ptger2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125199	Chr14:45225621-45225635 (+)	-24 bp
Tssr125200	Chr14:45225649-45225660 (+)	3 bp
Tssr125201	Chr14:45225913-45225929 (+)	269 bp
Tssr125202	Chr14:45226033-45226068 (+)	399 bp
Tssr125203	Chr14:45226110-45226129 (+)	468 bp
Tssr125204	Chr14:45226353-45226376 (+)	713 bp
Tssr125205	Chr14:45234627-45234648 (+)	8,986 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23