Prkcq MGI Mouse Gene Detail - MGI:97601

Symbol

Prkcq
Name

protein kinase C, theta
Synonyms

A130035A12Rik, PKC-0, Pkcq, PKCtheta, PKC theta, PKC-theta

Feature Type

protein coding gene
IDs

MGI:97601
NCBI Gene: 18761
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr2:11176919-11306033 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 8.42 cM
Mapping Data

4 experiments

SNPs within 2kb

438 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97601	protein coding gene	Chr2:11176716-11306037 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025342	protein coding gene	Chr2:8550608-8693011 (+)
A/J	MGP_AJ_G0025319	protein coding gene	Chr2:8195232-8332390 (+)
AKR/J	MGP_AKRJ_G0025288	protein coding gene	Chr2:8481233-8622714 (+)
BALB/cJ	MGP_BALBcJ_G0025315	protein coding gene	Chr2:8182932-8312340 (+)
C3H/HeJ	MGP_C3HHeJ_G0025075	protein coding gene	Chr2:8400231-8540565 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025757	protein coding gene	Chr2:8797431-8941146 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023171	protein coding gene	Chr2:7649588-7781056 (+)
CAST/EiJ	MGP_CASTEiJ_G0024538	protein coding gene	Chr2:8418887-8567031 (+)
CBA/J	MGP_CBAJ_G0025054	protein coding gene	Chr2:9137392-9286460 (+)
DBA/2J	MGP_DBA2J_G0025186	protein coding gene	Chr2:8119569-8252984 (+)
FVB/NJ	MGP_FVBNJ_G0025148	protein coding gene	Chr2:8047934-8177558 (+)
LP/J	MGP_LPJ_G0025272	protein coding gene	Chr2:8474391-8614073 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025180	protein coding gene	Chr2:9065668-9204220 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025815	protein coding gene	Chr2:8408348-8550173 (+)
PWK/PhJ	MGP_PWKPhJ_G0024289	protein coding gene	Chr2:8072026-8209696 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024089	protein coding gene	Chr2:8320245-8528753 (+)
WSB/EiJ	MGP_WSBEiJ_G0024608	protein coding gene	Chr2:8490546-8625040 (+)

Human Ortholog

PRKCQ, protein kinase C theta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKCQ, protein kinase C theta
Synonyms

nPKC-theta, PRKCT
Links

HGNC:9410

NCBI Gene ID: 5588

neXtProt AC: NX_Q04759

UniProt: Q04759
Chr Location

10p15.1; chr10:6393038-6580646 (-) GRCh38.p7

Alliance of Genome Resources

Prkcq stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRKCQ
Protein SuperFamily

PKC_delta
Gene Tree

Prkcq

Diseases

1 with Prkcq mouse models

Human Disease

Mouse Models

retinal detachment

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

55 phenotypes from 6 alleles in 9 genetic backgrounds
32 phenotypes from multigenic genotypes
106 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

2
Endonuclease-mediated

3
Spontaneous

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit reduced T cell proliferative responses and interleukin 2 production and a lack of T cell receptor-initiated NF-kappaB activation in mature T lymphocytes.

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All GO Annotations

60
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

957
Tissues

103
cDNA Data

39
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkcq

ZFIN prkcq

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Prkcq interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

56
RefSeq

8
UniProt

7
CCDS

CCDS15682.1

Ensembl

ENSMUSG00000026778 (Evidence)
NCBI Gene

18761

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026778	Ensembl Gene Model \| MGI Sequence Detail	129115	C57BL/6J	± kb
transcript	ENSMUST00000028118	Ensembl \| MGI Sequence Detail	3583	Not Applicable
polypeptide	ENSMUSP00000028118	Ensembl \| MGI Sequence Detail	707	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000002344 protein kinase C theta type

(term hierarchy)
PDB

4FKD
EC

2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR034668 Novel protein kinase C theta, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR014376 Protein kinase C, delta/epsilon/eta/theta types

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR027264 Protein kinase C, theta

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 41

cDNA 39

Primer pair 2

Microarray probesets 4

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MGD-MRK-13333, MGI:2139356, MGI:2442369

Summaries

All 199

Developmental Gene Expression 14

Diseases 1

Gene Ontology 20

Phenotypes 106
Earliest

J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
Latest

J:333420 Park J, et al., The Pellino1-PKCtheta Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function. Cancer Immunol Res. 2022 Mar 1;10(3):327-342

TSS for Prkcq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16098	Chr2:11176692-11176726 (+)	-210 bp
Tssr16099	Chr2:11176844-11176864 (+)	-65 bp
Tssr16100	Chr2:11176865-11176883 (+)	-45 bp
Tssr16101	Chr2:11176891-11176951 (+)	2 bp
Tssr402	Chr2:11176951-11176956 (+)	35 bp
Tssr16102	Chr2:11176972-11176983 (+)	59 bp
Tssr16103	Chr2:11176993-11177010 (+)	83 bp
Tssr16104	Chr2:11177027-11177048 (+)	119 bp
Tssr16105	Chr2:11177099-11177113 (+)	187 bp
Tssr16106	Chr2:11177120-11177138 (+)	210 bp
Tssr16107	Chr2:11177140-11177161 (+)	232 bp
Tssr16108	Chr2:11177167-11177178 (+)	254 bp
Tssr403	Chr2:11177193-11177196 (+)	276 bp
Tssr16109	Chr2:11177199-11177230 (+)	296 bp
Tssr16110	Chr2:11180674-11180684 (+)	3,760 bp
Tssr16111	Chr2:11210836-11210846 (+)	33,922 bp
Tssr16112	Chr2:11210920-11210923 (+)	34,003 bp
Tssr16113	Chr2:11223260-11223273 (+)	46,348 bp
Tssr16114	Chr2:11223304-11223315 (+)	46,391 bp
Tssr16115	Chr2:11255253-11255260 (+)	78,338 bp
Tssr16116	Chr2:11255273-11255285 (+)	78,360 bp
Tssr16117	Chr2:11255286-11255296 (+)	78,372 bp
Tssr16118	Chr2:11255298-11255309 (+)	78,385 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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