Sequence Detail

ID/Version

Q02111 (UniProt | EBI)

Last sequence update: 1993-07-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Protein kinase C theta type; EC=2.7.11.13 {ECO:0000250|UniProtKB:Q04759};AltName: Full=nPKC-theta;

Provider

SWISS-PROT

Sequence

Polypeptide 707 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkcq	protein kinase C, theta	64	104	3	11

Sequence references in MGI

J:13213 Osada S, et al., A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992 Sep;12(9):3930-8
J:83733 Pfeifhofer C, et al., Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med. 2003 Jun 2;197(11):1525-35
J:83922 Sun Z, et al., PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000 Mar 23;404(6776):402-7
J:100165 Marsland BJ, et al., Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J Exp Med. 2004 Jul 19;200(2):181-9
J:129421 Tan SL, et al., Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice. J Immunol. 2006 Mar 1;176(5):2872-9
J:146938 Wang C, et al., Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. J Biol Chem. 2009 Jan 23;284(4):2038-44
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89