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Mbp Gene Detail
Summary
  • Symbol
    Mbp
  • Name
    myelin basic protein
  • Synonyms
    golli-mbp, Hmbpr, jve
  • Feature Type
    protein coding gene
  • IDs
    MGI:96925
    NCBI Gene: 17196
  • Alliance
  • Transcription Start Sites
    45 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:82493271-82603762 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 55.84 cM, cytoband E2-E4
  • Mapping Data
    42 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3454 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96925
protein coding gene Chr18:82492883-82603762 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024601
protein coding gene Chr18:83503099-83625563 (+)
A/J MGP_AJ_G0024568
protein coding gene Chr18:79857765-79975533 (+)
AKR/J MGP_AKRJ_G0024539
protein coding gene Chr18:82223240-82339100 (+)
BALB/cJ MGP_BALBcJ_G0024566
protein coding gene Chr18:80046344-80159892 (+)
C3H/HeJ MGP_C3HHeJ_G0024335
protein coding gene Chr18:82333972-82454397 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025013
protein coding gene Chr18:85561903-85688547 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022444
protein coding gene Chr18:78620687-78731252 (+)
CAST/EiJ MGP_CASTEiJ_G0023808
protein coding gene Chr18:82638906-82760379 (+)
CBA/J MGP_CBAJ_G0024305
protein coding gene Chr18:88750575-88875395 (+)
DBA/2J MGP_DBA2J_G0024435
protein coding gene Chr18:79382760-79495264 (+)
FVB/NJ MGP_FVBNJ_G0024401
protein coding gene Chr18:78687454-78802850 (+)
LP/J MGP_LPJ_G0024519
protein coding gene Chr18:83320775-83438306 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024431
protein coding gene Chr18:89967743-90087998 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025062
protein coding gene Chr18:82398753-82513604 (+)
PWK/PhJ MGP_PWKPhJ_G0023553
protein coding gene Chr18:79753130-79878926 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023359
protein coding gene Chr18:82515685-82625844 (+)
WSB/EiJ MGP_WSBEiJ_G0023870
protein coding gene Chr18:82376809-82496798 (+)



Homology
more
  • Human Ortholog
    MBP, myelin basic protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBP, myelin basic protein
  • Links
    NCBI Gene ID: 4155
    neXtProt AC: NX_P02686
    UniProt: P02686

  • Chr Location
    18q23; chr18:76978827-77133708 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human MBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 5 alleles in 11 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    170 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered myelination, oligodendrocytes, Ca2+ responses, and visual-evoked potentials. Spontaneous mutations cause dymyelination, tremors and ataxia, and may alter survival, susceptibility to seizures, viral infection and EAE, and hearing or vestibular function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041607 Ensembl Gene Model | MGI Sequence Detail 110492 C57BL/6J ±  kb
    transcript ENSMUST00000047865 Ensembl | MGI Sequence Detail 2492 Not Applicable  
    polypeptide ENSMUSP00000046185 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 18
      cDNA 42
      Primer pair 22
      Other 28

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10746, MGD-MRK-12126, MGD-MRK-12253, MGD-MRK-14404, MGI:2147393, MGI:2147422, MGI:3708158
    References
    more
    • Summaries
      All 627
      Developmental Gene Expression 284
      Gene Ontology 21
      Phenotypes 170
    • Earliest
      J:5917 Doolittle DP, et al., Myelin deficient, a new neurological mutant in the mouse. J Hered. 1977 Sep-Oct;68(5):331-2
    • Latest
      J:353383 MacArthur IC, et al., Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence. Sci Adv. 2024 Aug 30;10(35):eado5424

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/05/2024
    MGI 6.24
    The Jackson Laboratory