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Lipe Gene Detail
Summary
  • Symbol
    Lipe
  • Name
    lipase E, hormone sensitive type
  • Synonyms
    4933403G17Rik, HSL
  • Feature Type
    protein coding gene
  • IDs
    MGI:96790
    NCBI Gene: 16890
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25078952-25097911 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.78 cM, cytoband A3
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    477 from dbSNP Build 142
  • Strain Annotations
    26
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96790
 protein coding gene Chr7:25078952-25098135 (-)
129S1/SvImJ ENSMUSGG00200054974
 protein coding gene Chr7:15082710-15099557 (-)
129S1/SvImJ ENSMUSG00200041090
 protein coding gene Chr7:15100637-15101887 (-)
A/J ENSMUSG00195052449
 protein coding gene Chr7:17537841-17539091 (-)
A/J ENSMUSGG00195055384
 protein coding gene Chr7:17519926-17536761 (-)
AKR/J ENSMUSGG00220054972
 protein coding gene Chr7:26853807-26870653 (+)
AKR/J ENSMUSG00220049749
 protein coding gene Chr7:26851477-26852727 (+)
BALB/cJ ENSMUSGG00180055633
 protein coding gene Chr7:15591895-15608739 (-)
BALB/cJ ENSMUSG00180053337
 protein coding gene Chr7:15609819-15611069 (-)
C3H/HeJ ENSMUSGG00175055143
 protein coding gene Chr7:16635994-16652847 (-)
C3H/HeJ ENSMUSG00175045349
 protein coding gene Chr7:16653927-16655177 (-)
C57BL/6NJ ENSMUSGG00215055842
 protein coding gene Chr7:14995838-15012691 (-)
C57BL/6NJ ENSMUSG00215054705
 protein coding gene Chr7:15013771-15015021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029368
 protein coding gene Chr7:24649615-24668724 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052320
 protein coding gene Chr7:15839640-15840890 (-)
CBA/J ENSMUSGG00210055077
 protein coding gene Chr7:15821715-15838560 (-)
DBA/2J ENSMUSG00185054105
 protein coding gene Chr7:19053410-19054660 (-)
DBA/2J ENSMUSGG00185057369
 protein coding gene Chr7:19035482-19052330 (-)
FVB/NJ ENSMUSG00205044287
 protein coding gene Chr7:15850267-15851517 (-)
FVB/NJ ENSMUSGG00205054655
 protein coding gene Chr7:15832332-15849187 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230052622
 protein coding gene Chr7:24326781-24328031 (-)
LP/J ENSMUSGG00230055940
 protein coding gene Chr7:24308853-24325701 (-)
NOD/ShiLtJ ENSMUSGG00190054497
 protein coding gene Chr7:15302594-15319473 (-)
NZO/HlLtJ ENSMUSGG00225055742
 protein coding gene Chr7:22977476-22994320 (-)
NZO/HlLtJ ENSMUSG00225023187
 protein coding gene Chr7:22995400-22996650 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010049261
 protein coding gene Chr7:14929937-14949178 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
  • Synonyms
    AOMS4, FPLD6, HSL, LHS, REH
  • Links
    NCBI Gene ID: 3991
    UniProt: Q05469

  • Chr Location
    19q13.2; chr19:42401497-42427388 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LIPE associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 6 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    11
  • cDNA Data
    9
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16890 NCBI Gene Model | MGI Sequence Detail 18960 C57BL/6J ±  kb
    transcript NM_010719 RefSeq | MGI Sequence Detail 3221 C57BL/6  
    polypeptide P54310 UniProt | EBI | MGI Sequence Detail 759 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 10
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11812, MGI:1918310
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 16
      Gene Ontology 27
      Phenotypes 88
    • Earliest
      J:13548 Clamp PA, et al., Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6. Genomics. 1993 Aug;17(2):324-9
    • Latest
      J:363294 Wang S, et al., SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2025 Mar;32(3):447-465
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory