About Help FAQ

Symbol
Name
ID

Lipe
lipase, hormone sensitive
MGI:96790

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Abnormal circulating lipid concentration	Hyperlipidemia	Hypertriglyceridemia	Elevated circulating creatine kinase concentration	Diabetes mellitus	Insulin-resistant diabetes mellitus	Insulin resistance	Hepatic steatosis	Decreased adiponectin level	Decreased serum leptin
Disease(s) Associated with LIPE
familial partial lipodystrophy type 6

Mouse Phenotypes

decreased cardiac muscle triglyceride level

abnormal insulin secretion

decreased susceptibility to diet-induced obesity

increased circulating glucose level

hyperglycemia

decreased circulating insulin level

increased circulating insulin level

decreased circulating leptin level

increased circulating leptin level

abnormal circulating cholesterol level

increased circulating cholesterol level

abnormal circulating free fatty acids level

decreased circulating free fatty acids level

increased circulating free fatty acids level

decreased circulating glycerol level

decreased circulating triglyceride level

increased circulating triglyceride level

increased oxygen consumption

abnormal glucose homeostasis

impaired glucose tolerance

decreased skeletal muscle glycogen level

abnormal hepatic glucose production

insulin resistance

decreased circulating adiponectin level

abnormal lipid homeostasis

abnormal cholesterol homeostasis

abnormal lipid level

abnormal fatty acids level

abnormal triglyceride level

decreased liver triglyceride level

increased triglyceride level

abnormal metabolism

abnormal enzyme/coenzyme activity

abnormal lipolysis

Availability

Mouse Genotype

Lipe^{tm1b(KOMP)Wtsi}/Lipe^{tm1b(KOMP)Wtsi}

Lipe^tm1Gam/Lipe^tm1Gam

Lipe^tm1Ishi/Lipe^tm1Ishi

Lipe^tm1Land/Lipe^tm1Land

Lipe^tm1Rze/Lipe^tm1Rze

Lipe^tm2Rze/Lipe^tm2Rze
Tg(Ins2-cre)25Mgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23