Lif MGI Mouse Gene Detail - MGI:96787 - leukemia inhibitory factor

Symbol

Lif
Name

leukemia inhibitory factor

Feature Type

protein coding gene
IDs

MGI:96787
NCBI Gene: 16878
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:4207568-4222514 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.94 cM, cytoband A1-A2
Mapping Data

18 experiments
Sequence Tags

D11Mit106, D11Mit16

SNPs within 2kb

62 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96787	protein coding gene	Chr11:4207557-4222514 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017981	protein coding gene	Chr11:1193323-1220046 (+)
A/J	MGP_AJ_G0017954	protein coding gene	Chr11:1202123-1217346 (+)
AKR/J	MGP_AKRJ_G0017918	protein coding gene	Chr11:1257095-1272357 (+)
BALB/cJ	MGP_BALBcJ_G0017922	protein coding gene	Chr11:1173462-1188937 (+)
C3H/HeJ	MGP_C3HHeJ_G0017735	protein coding gene	Chr11:1156755-1171733 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018375	protein coding gene	Chr11:1273900-1291663 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016033	protein coding gene	Chr11:1082086-1097774 (+)
CAST/EiJ	MGP_CASTEiJ_G0017297	protein coding gene	Chr11:1119976-1137762 (+)
CBA/J	MGP_CBAJ_G0017710	protein coding gene	Chr11:1519721-1535714 (+)
DBA/2J	MGP_DBA2J_G0017821	protein coding gene	Chr11:1107465-1122529 (+)
FVB/NJ	MGP_FVBNJ_G0017812	protein coding gene	Chr11:1139940-1154915 (+)
LP/J	MGP_LPJ_G0017891	protein coding gene	Chr11:1298668-1313553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017838	protein coding gene	Chr11:1184020-1211104 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018414	protein coding gene	Chr11:1267918-1283208 (+)
PWK/PhJ	MGP_PWKPhJ_G0017078	protein coding gene	Chr11:1109892-1125406 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016874	protein coding gene	Chr11:1229582-1246654 (+)
WSB/EiJ	MGP_WSBEiJ_G0017351	protein coding gene	Chr11:1130825-1146101 (+)

Human Ortholog

LIF, LIF interleukin 6 family cytokine

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIF, LIF interleukin 6 family cytokine
Synonyms

CDF, DIA, HILDA, MLPLI
Links

HGNC:6596

NCBI Gene ID: 3976

neXtProt AC: NX_P15018

UniProt: P15018
Chr Location

22q12.2; chr22:30240447-30246851 (-) GRCh38.p7

Alliance of Genome Resources

Lif stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LIF
Gene Tree

Lif

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Phenotype Summary

67 phenotypes from 3 alleles in 9 genetic backgrounds
38 phenotypes from multigenic genotypes
69 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations have reduced numbers of stem cells in spleen and bone marrow, enhanced inflammatory responses, impaired sensory neuron regrowth, and uterine insufficiency. Heterozygotes show intermediate numbers of stem cells.

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All GO Annotations

77
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

939
Tissues

140
cDNA Data

21
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Lif interacts with 277 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

55
RefSeq

10
UniProt

3
CCDS

CCDS24383.1, CCDS24384.1

Ensembl

ENSMUSG00000034394 (Evidence)
NCBI Gene

16878

			Length	Strain/Species	Flank
genomic	16878	NCBI Gene Model \| MGI Sequence Detail	14947	C57BL/6J	± kb
transcript	NM_001039537	RefSeq \| MGI Sequence Detail	4221	C57BL/6
polypeptide	P09056	UniProt \| EBI \| MGI Sequence Detail	203	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009799 leukemia inhibitory factor

(term hierarchy)
PDB

1A7M, 1LKI
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR003624 Leukemia inhibitory factor

IPR001581 Leukemia inhibitory factor /oncostatin

IPR019827 Leukemia inhibitory factor /oncostatin, conserved site

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All nucleic 43

Genomic 7

cDNA 24

Primer pair 9

Other 3

Microarray probesets 5

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MGD-MRK-11807

Summaries

All 243

Developmental Gene Expression 45

Gene Ontology 19

Phenotypes 69
Earliest

J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
Latest

J:331688 Hashimoto M, et al., Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1. Front Neurosci. 2022;16:948517

TSS for Lif:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100118	Chr11:4207581-4207592 (+)	19 bp
Tssr100119	Chr11:4210823-4210824 (+)	3,256 bp
Tssr3415	Chr11:4210878-4210915 (+)	3,329 bp
Tssr3416	Chr11:4211568-4211599 (+)	4,016 bp
Tssr100120	Chr11:4214300-4214313 (+)	6,739 bp
Tssr100121	Chr11:4215244-4215264 (+)	7,686 bp
Tssr100122	Chr11:4216481-4216497 (+)	8,921 bp
Tssr100123	Chr11:4216525-4216544 (+)	8,967 bp
Tssr100124	Chr11:4216667-4216673 (+)	9,102 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 05/30/2023 MGI 6.22