Sequence Detail

ID/Version

P09056 (UniProt | EBI)

Last sequence update: 1988-11-01
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Leukemia inhibitory factor {ECO:0000303|PubMed:3186448}; Short=LIF {ECO:0000303|PubMed:3186448};AltName: Full=Differentiation-stimulating factor {ECO:0000303|PubMed:2475312}; Short=D factor {ECO:0000303|PubMed:2475312};Flags:

Provider

SWISS-PROT

Sequence

Polypeptide 203 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lif	leukemia inhibitory factor	99	122	2	16

Sequence references in MGI

J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
J:10516 Stahl J, et al., Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions. J Biol Chem. 1990 May 25;265(15):8833-41
J:15510 Gearing DP, et al., Complete sequence of murine myeloid leukaemia inhibitory factor (LIF). Nucleic Acids Res. 1988 Oct 25;16(20):9857
J:35071 Stewart CL, et al., Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor [see comments]. Nature. 1992 Sep 3;359(6390):76-9
J:47948 Hinds MG, et al., Solution structure of leukemia inhibitory factor. J Biol Chem. 1998 May 29;273(22):13738-45
J:56752 Teuscher C, et al., Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. J Immunol. 1999 Aug 15;163(4):2262-6
J:105174 Song H, et al., Evidence for heterodimeric association of leukemia inhibitory factor (LIF) receptor and gp130 in the mouse uterus for LIF signaling during blastocyst implantation. Reproduction. 2006 Feb;131(2):341-9
J:381432 Paling NR, et al., Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem. 2004 Nov 12;279(46):48063-70
J:381453 Williams RL, et al., Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature. 1988 Dec 15;336(6200):684-7
J:381463 Kunisada K, et al., Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. Circulation. 1996 Nov 15;94(10):2626-32
J:381465 Oh H, et al., Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes. J Biol Chem. 1998 Apr 17;273(16):9703-10