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Krt19 Gene Detail
Summary
  • Symbol
    Krt19
  • Name
    keratin 19
  • Synonyms
    cytokeratin19, cytokeratin 19, cytokeratin-19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344
  • Feature Type
    protein coding gene
  • IDs
    MGI:96693
    NCBI Gene: 16669
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100031636-100036752 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.42 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96693
 protein coding gene Chr11:100031636-100039491 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019143
 protein coding gene Chr11:102889238-102897097 (-)
A/J MGP_AJ_G0019111
 protein coding gene Chr11:98546453-98554672 (-)
AKR/J MGP_AKRJ_G0019080
 protein coding gene Chr11:101591190-101599049 (-)
BALB/cJ MGP_BALBcJ_G0019085
 protein coding gene Chr11:99062960-99070790 (-)
C3H/HeJ MGP_C3HHeJ_G0018894
 protein coding gene Chr11:101790503-101798358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019534
 protein coding gene Chr11:106056636-106064493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017161
 protein coding gene Chr11:96001166-96009090 (-)
CAST/EiJ MGP_CASTEiJ_G0018448
 protein coding gene Chr11:102771023-102778653 (-)
CBA/J MGP_CBAJ_G0018863
 protein coding gene Chr11:110492052-110499882 (-)
DBA/2J MGP_DBA2J_G0018976
 protein coding gene Chr11:98121541-98129400 (-)
FVB/NJ MGP_FVBNJ_G0018965
 protein coding gene Chr11:97622655-97631685 (-)
LP/J MGP_LPJ_G0019044
 protein coding gene Chr11:103427705-103436059 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018996
 protein coding gene Chr11:110116327-110124169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019572
 protein coding gene Chr11:101968696-101976526 (-)
PWK/PhJ MGP_PWKPhJ_G0018211
 protein coding gene Chr11:99152740-99161063 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018003
 protein coding gene Chr11:101669886-101679171 (-)
WSB/EiJ MGP_WSBEiJ_G0018497
 protein coding gene Chr11:101936445-101944277 (-)



Homology
more
  • Human Ortholog
    KRT19, keratin 19
  • Vertebrate Orthologs
    16
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT19, keratin 19
  • Synonyms
    CK19, K19, K1CS
  • Links
    NCBI Gene ID: 3880
    neXtProt AC: NX_P08727
    UniProt: P08727

  • Chr Location
    17q21.2; chr17:41523617-41528308 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    51 phenotypes from multigenic genotypes
    2 images
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1231
  • Tissues
    156
  • cDNA Data
    296
  • Literature Summary
    148
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16669 NCBI Gene Model | MGI Sequence Detail 5117 C57BL/6J ±  kb
transcript NM_008471 RefSeq | MGI Sequence Detail 1396 ZRU/MplStud  
polypeptide P19001 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 317
    Genomic 10
    cDNA 296
    Primer pair 11

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11633, MGD-MRK-11648, MGI:2144260
References
more
  • Summaries
    All 287
    Developmental Gene Expression 148
    Gene Ontology 11
    Phenotypes 109
  • Earliest
    J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
  • Latest
    J:346123 Darrigrand JF, et al., Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner. Dev Cell. 2024 Feb 5;59(3):326-338.e5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory