Hspa1a MGI Mouse Gene Detail - MGI:96244 - heat shock protein family A (Hsp70) member 1A

Symbol

Hspa1a
Name

heat shock protein family A (Hsp70) member 1A
Synonyms

Hsp68, Hsp70-3, Hsp70.3, Hsp70a1

Feature Type

protein coding gene
IDs

MGI:96244
NCBI Gene: 193740
Alliance

genome feature page
Transcription Start Sites

3 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr17:35188335-35191132 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.51 cM
Mapping Data

12 experiments

Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96244	protein coding gene	Chr17:35188166-35191132 (-)
129S1/SvImJ	ENSMUSG00200049213	protein coding gene	Chr17:30892276-30895242 (-)
A/J	ENSMUSG00195041629	protein coding gene	Chr17:31792424-31795390 (-)
AKR/J	ENSMUSG00220050058	protein coding gene	Chr17:30821104-30824070 (-)
BALB/cJ	ENSMUSG00180039801	protein coding gene	Chr17:31162296-31165262 (-)
C3H/HeJ	ENSMUSG00175034748	protein coding gene	Chr17:30707211-30710177 (-)
C57BL/6NJ	ENSMUSG00215051478	protein coding gene	Chr17:30732478-30735444 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021488	protein coding gene	Chr17:31712212-31715172 (-)
CAST/EiJ	ENSTCUG00005048750	protein coding gene	Chr17:31750829-31753795 (-)
CBA/J	ENSMUSG00210047058	protein coding gene	Chr17:30529329-30532295 (-)
DBA/2J	ENSMUSG00185051249	protein coding gene	Chr17:33181542-33184508 (-)
FVB/NJ	ENSMUSG00205030032	protein coding gene	Chr17:31050867-31053815 (-)
JF1/MsJ	ENSUMUG00000056953	protein coding gene	Chr17:32434417-32437382 (-)
LP/J	ENSMUSG00230054599	protein coding gene	Chr17:34290534-34293500 (-)
NOD/ShiLtJ	ENSMUSG00190052644	protein coding gene	Chr17:30651777-30654725 (-)
NZO/HlLtJ	ENSMUSG00225054784	protein coding gene	Chr17:36303460-36306426 (-)
PWK/PhJ	ENSLUMG00010039362	protein coding gene	Chr17:30268902-30271868 (-)
SPRET/EiJ	ENSMSPG00010033011	protein coding gene	Chr17:31442642-31445353 (-)
WSB/EiJ	ENSIUOG00005042810	protein coding gene	Chr17:31379399-31382357 (-)

Human Ortholog

HSPA1A, heat shock protein family A (Hsp70) member 1A

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA1A, heat shock protein family A (Hsp70) member 1A
Synonyms

HEL-S-103, HSP70, HSP70-1, HSP70.1, HSP70-1A, HSP70-2, HSP70.2, HSP70I, HSP72, HSPA1
Links

HGNC:5232

NCBI Gene ID: 3303

UniProt: P0DMV8
Chr Location

6p21.33; chr6:31815543-31817994 (+) GRCh38

MGI Vertebrate Homology

Hspa1a stringent orthology
1 human;1 mouse;2 rat;4 zebrafish
HCOP

vertebrate homology predictions: HSPA1A
Gene Tree

Hspa1a

Diseases

14 with human HSPA1A associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				atherosclerosis IDs atherosclerosis DOID:1936 EFO:0003914 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C35768 UMLS_CUI:C0004153
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				idiopathic pulmonary fibrosis IDs idiopathic pulmonary fibrosis DOID:0050156 EFO:0000768 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35716 UMLS_CUI:C1800706
				Kawasaki disease IDs Kawasaki disease DOID:13378 EFO:0004246 ICD10CM:M30.3 ICD9CM_2006:446.1 ICD9CM:446.1 MESH:D009080 NCI:C34825 OMIM:611775 UMLS_CUI:C0026691
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C195908 NCI:C34796 OMIM:608516 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				Meniere's disease IDs Meniere's disease DOID:9849 ICD10CM:H81.0 ICD9CM:386.0 ICD9CM:386.00 MESH:D008575 NCI:C185243 OMIM:156000 UMLS_CUI:C0025281
				paranoid schizophrenia IDs paranoid schizophrenia DOID:1229 DOID:11238 DOID:1230 ICD10CM:F20.0 ICD9CM_2006:295.3 ICD9CM:295.3 ICD9CM:295.30 ICD9CM:295.31 ICD9CM:295.32 MESH:D012563 NCI:C35006 UMLS_CUI:C0036349 UMLS_CUI:C0270398
				Parkinsonism IDs Parkinsonism DOID:0080855
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				vascular dementia IDs vascular dementia DOID:8725 DOID:13915 ICD10CM:F01 ICD9CM:290.4 MESH:D015140 MESH:D015161 NCI:C34522 NCI:C34525 UMLS_CUI:C0011263 UMLS_CUI:C0011269
				vitiligo IDs vitiligo DOID:12306 EFO:0004208 ICD10CM:L80 ICD9CM:709.01 MESH:D014820 NCI:C26915 OMIM:193200 UMLS_CUI:C0042900

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 1 genetic background
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Hspa1a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

24 strains or lines available

At the cellular level, mice homozygous for a knock-out allele exhibit impaired thermotolerance and increased sensitivity to heat stress-induced apoptosis.

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All GO Annotations

109
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

657
Tissues

30
cDNA Data

40
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa1a

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All Sequences

38
RefSeq

2
UniProt

1
CCDS

CCDS50080.1

Ensembl

ENSMUSG00000091971 (Evidence)
NCBI Gene

193740

			Length	Strain/Species	Flank
genomic	193740	NCBI Gene Model \| MGI Sequence Detail	2798	C57BL/6J	± kb
transcript	NM_010479	RefSeq \| MGI Sequence Detail	2798	C57BL/6
polypeptide	Q61696	UniProt \| EBI \| MGI Sequence Detail	641	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008871 heat shock 70 kDa protein 1A

(term hierarchy)
GlyGen

Q61696 2 sites, 1 O-linked glycan (1 site)

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All nucleic 58

Genomic 16

cDNA 40

Primer pair 2

Antibodies 2

Microarray probesets 3

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MGD-MRK-10960

Summaries

All 149

Developmental Gene Expression 16

Gene Ontology 15

Phenotypes 57
Earliest

J:14783 Lowe DG, et al., Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs. J Biol Chem. 1986 Feb 15;261(5):2102-12
Latest

J:373902 Kang X, et al., Dual roles of in situ generated HSP70 in antigen delivery and immunoregulation. Front Immunol. 2025;16:1638948

TSS for Hspa1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147705	Chr17:35191126-35191134 (-)	2 bp
Tssr147704	Chr17:35188780-35188783 (-)	2,350 bp
Tssr147703	Chr17:35188394-35188403 (-)	2,733 bp

Hspa1a is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs5	Chr17, syntenic		J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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