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Gria2 Gene Detail
Summary
  • Symbol
    Gria2
  • Name
    glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • Synonyms
    GluA2, Glur2, Glur-2, GluR2, GluR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95809
    NCBI Gene: 14800
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:80588757-80710142 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 35.50 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    706 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95809
protein coding gene Chr3:80588757-80711534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027319
protein coding gene Chr3:80437104-80560161 (-)
A/J MGP_AJ_G0027281
protein coding gene Chr3:77779219-77895500 (-)
AKR/J MGP_AKRJ_G0027249
protein coding gene Chr3:79580985-79705608 (-)
BALB/cJ MGP_BALBcJ_G0027292
protein coding gene Chr3:77841429-77962358 (-)
C3H/HeJ MGP_C3HHeJ_G0027036
protein coding gene Chr3:79918083-80041982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027738
protein coding gene Chr3:83500410-83631888 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025091
protein coding gene Chr3:73603768-73722255 (-)
CAST/EiJ MGP_CASTEiJ_G0026483
protein coding gene Chr3:80018049-80146468 (-)
CBA/J MGP_CBAJ_G0027011
protein coding gene Chr3:86265256-86399223 (-)
DBA/2J MGP_DBA2J_G0027147
protein coding gene Chr3:77328468-77445608 (-)
FVB/NJ MGP_FVBNJ_G0027115
protein coding gene Chr3:75664150-75781521 (-)
LP/J MGP_LPJ_G0027255
protein coding gene Chr3:81423845-81550827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027134
protein coding gene Chr3:92564923-92709190 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027796
protein coding gene Chr3:79413740-79538797 (-)
PWK/PhJ MGP_PWKPhJ_G0026217
protein coding gene Chr3:77078510-77197634 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026033
protein coding gene Chr3:78599386-78728956 (-)
WSB/EiJ MGP_WSBEiJ_G0026561
protein coding gene Chr3:79752099-79876199 (-)



Homology
more
  • Human Ortholog
    GRIA2, glutamate ionotropic receptor AMPA type subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA2, glutamate ionotropic receptor AMPA type subunit 2
  • Synonyms
    GluA2, gluR-2, GLUR2, gluR-B, GLURB, GluR-K2, HBGR2, NEDLIB
  • Links
    NCBI Gene ID: 2891
    neXtProt AC: NX_P42262
    UniProt: P42262

  • Chr Location
    4q32.1; chr4:157204182-157387146 (+)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 14 alleles in 16 genetic backgrounds
    32 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033981 Ensembl Gene Model | MGI Sequence Detail 121386 C57BL/6J ±  kb
    transcript ENSMUST00000075316 Ensembl | MGI Sequence Detail 10371 Not Applicable  
    polypeptide ENSMUSP00000074787 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 6
      cDNA 24
      Primer pair 2
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10141, MGD-MRK-10148, MGD-MRK-10247
    References
    more
    • Summaries
      All 304
      Developmental Gene Expression 67
      Diseases 1
      Gene Ontology 32
      Phenotypes 113
    • Earliest
      J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
    • Latest
      J:345696 Lebedeva M, et al., The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2(R/R) mice; a comparison with C57BL/6J and Adar2(-/-) mice strains. Brain Res. 2024 Mar 1;1826:148739

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    04/09/2024
    MGI 6.23
    The Jackson Laboratory