Ccn2 MGI Mouse Gene Detail - MGI:95537 - cellular communication network factor 2

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Ccn2 Gene Detail

Symbol

Ccn2
Name

cellular communication network factor 2
Synonyms

Ccn2, Ctgf, Fisp12, Hcs24, hypertrophic chondrocyte-specific gene product 24

Feature Type

protein coding gene
IDs

MGI:95537
NCBI Gene: 14219
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr10:24471340-24474581 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 11.84 cM, cytoband A3-B1
Mapping Data

5 experiments

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SNPs within 2kb

44 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95537	protein coding gene	Chr10:24471340-24474581 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017092	protein coding gene	Chr10:22576348-22579589 (+)
A/J	MGP_AJ_G0017069	protein coding gene	Chr10:21914646-21917887 (+)
AKR/J	MGP_AKRJ_G0017029	protein coding gene	Chr10:22275588-22278829 (+)
BALB/cJ	MGP_BALBcJ_G0017032	protein coding gene	Chr10:22011419-22014660 (+)
C3H/HeJ	MGP_C3HHeJ_G0016852	protein coding gene	Chr10:22483518-22486759 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017490	protein coding gene	Chr10:23273404-23276645 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015188	protein coding gene	Chr10:20610892-20613012 (+)
CAST/EiJ	MGP_CASTEiJ_G0016431	protein coding gene	Chr10:22423889-22428687 (+)
CBA/J	MGP_CBAJ_G0016826	protein coding gene	Chr10:24315971-24319212 (+)
DBA/2J	MGP_DBA2J_G0016931	protein coding gene	Chr10:21645226-21648769 (+)
FVB/NJ	MGP_FVBNJ_G0016926	protein coding gene	Chr10:21350913-21354154 (+)
LP/J	MGP_LPJ_G0017008	protein coding gene	Chr10:22565560-22568801 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016956	protein coding gene	Chr10:24437600-24440841 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017526	protein coding gene	Chr10:22139856-22143081 (+)
PWK/PhJ	MGP_PWKPhJ_G0016213	protein coding gene	Chr10:21408827-21430352 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015997	protein coding gene	Chr10:21955178-21958824 (+)
WSB/EiJ	MGP_WSBEiJ_G0016494	protein coding gene	Chr10:22259871-22263988 (+)

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Human Ortholog

CCN2, cellular communication network factor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCN2, cellular communication network factor 2
Synonyms

CTGF, HCS24, IBP-8, IGFBP8, NOV2
Links

HGNC:2500

NCBI Gene ID: 1490

neXtProt AC: NX_P29279

UniProt: P29279
Chr Location

6q23.2; chr6:131948176-131951372 (-) GRCh38

MGI Vertebrate Homology

Ccn2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCN2
Protein SuperFamily

IGFBP_rP_CNN
Gene Tree

Ccn2

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Phenotype Summary

73 phenotypes from 7 alleles in 10 genetic backgrounds
3 phenotypes from multigenic genotypes
68 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

11
Transgenic

1
Genomic Mutations

1 involving Ccn2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice die at birth from respiratory failure due to axial skeletal defects and pulmonary hypoplasia associated with reduced cell proliferation, enhanced apoptosis and altered pneumocyte maturation. Osteogenesis is impaired due to impaired chondrogenesis and growth plate angiogenesis.

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All GO Annotations

57
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1708
Tissues

464
cDNA Data

149
Literature Summary

152

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccn2

ZFIN ccn2a, ccn2b

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS23751.1

Ensembl

ENSMUSG00000019997 (Evidence)
NCBI Gene

14219

Representative Sequences				Length	Strain/Species	Flank
	genomic	14219	NCBI Gene Model \| MGI Sequence Detail	3242	C57BL/6J	± kb
	transcript	NM_010217	RefSeq \| MGI Sequence Detail	2418	ZRU/MplStud
	polypeptide	P29268	UniProt \| EBI \| MGI Sequence Detail	348	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003172 CCN family member 2

(term hierarchy)
InterPro Domains

IPR043973 CCN, TSP1 domain

IPR006207 Cystine knot, C-terminal

IPR006208 Glycoprotein hormone subunit beta

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR012395 IGFBP-related, CNN

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR001007 VWFC domain

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All nucleic 167

Genomic 1

cDNA 153

Primer pair 12

Other 1

Microarray probesets 3

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MGD-MRK-9804

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Summaries

All 318

Developmental Gene Expression 152

Gene Ontology 17

Phenotypes 68
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344611 Wang Y, et al., CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development. JCI Insight. 2023 Jan 10;8(1)

TSS for Ccn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92733	Chr10:24471332-24471343 (+)	-2 bp
Tssr92734	Chr10:24471387-24471418 (+)	63 bp
Tssr92735	Chr10:24471521-24471528 (+)	185 bp
Tssr92736	Chr10:24471938-24471969 (+)	614 bp
Tssr92737	Chr10:24472337-24472354 (+)	1,006 bp

Ccn2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Lith21	Chr10, 12.51 cM	Chr10:25525003-25525126	J:133501	SNP analysis, mRNA microarray analysis and protein expression difference analysis were used to narrow the QTL intervals of 9 previously identified QTLs for HDL cholesterol (Hdlq1, Hdlq20, Hdlq24), gallstone susceptibility (Lith17, Lith19, Lith21) and obesity (Obwq3, Obwq4, Obwq5). This methodology identified a manageable list of potential candidate genes for each QTL. A panel of 130,000 SNPs for SM/J and NZB/BlNJ reduced the QTL intervals by 40%-72%. Liver mRNA analysis identified 10 genes differentially expressed between SM/J and NZB/BlNJ strains and this finding was confirmed using TaqMan RT-PCR assays. Mass spectrometry analysis of liver proteins identified 45 proteins displaying differential expression between SM/J andNZB/BlNJ. On mouse Chromosome 1, Apoa2 (92.6 cM), Fh1, and Hsd11b1 were identified as potential candidate genes for Hdlq20 at 96 cM. Apoa2 was identified based on protein expression and SNP coding sequence differences. Apoa2 displays up-regulation in NZB/BlNJ liver proteins comparedto SM/J. Fh1 displays gene coding sequence differences and decreased protein expression in NZB/BlNJ livers compared to SM/J. Hsd11b1 was identified based on decreased protein expression in NZB/BlNJ. On mouse Chromosome 5, Acads (65 cM) and Scarb1 (68 cM)were identified as potential candidate genes for Hdlq1 (70 cM) and Lith17 (60 cM). Acads was identified on the basis of decreased protein expression in NZB/BlNJ livers compared to SM/J, as well as coding sequence differences. Scarb1 displays coding regionsequence differences and decreased liver mRNA expression in NZB/BlNJ. Scarb1 is located more closely to Hdlq1 and decreased Scarb1 mRNA expression was observed for this QTL. On mouse Chromosome 6, Pparg (52.7 cM), Rassf4 and Adipor2 (60.7 cM) were identified as potential candidate genes for Hdlq24 (66 cM) and Obwq3 (42 cM). Pparg displays coding sequences differences between NZB/BlNJ and SM/J while Rassf4 displays decreased liver mRNA expression in NZB/BlNJ animals. Adipor2 displays increased liver mRNAexpression in NZB/BlNJ and gene coding sequence differences. Ndufa9 was identified as a QTL for Hdlq24 on the basis of decreased liver protein expression in NZB/BlNJ and coding sequence differences. On mouse Chromosome 8,Slc10a2 (2 cM) was identifiedasa potential candidate gene for Lith19 (0 cM) on the basis of increased liver mRNA expression in NZB/BlNJ animals compared to SM/J. On mouse Chromosome 10, Ctgf (17 cM) was identified as a potential candidate gene for Lith21 (24 cM)on the basis of decreased liver mRNA expression in NZB/BlNJ animals compared to SM/J and gene coding sequences differences. On mouse Chromosome 17, Pgc (30 cM) was identified as a potential candidate for Obwq4 (32 cM).Pgc displays coding sequence differences between NZB/BlNJand SM/J. Atrnl1 was identified as a candidate for Obwq5 (52 cM) on chromosome 19. Atrnl1 displays increased liver mRNA expression in NZB/BlNJ animals compared to SM/J.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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