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Fgf5 Gene Detail
Summary
  • Symbol
    Fgf5
  • Name
    fibroblast growth factor 5
  • Synonyms
    Fgf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95519
    NCBI Gene: 14176
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:98402108-98424892 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E1-F
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95519
 protein coding gene Chr5:98402043-98424892 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029773
 protein coding gene Chr5:99605143-99632376 (+)
A/J MGP_AJ_G0029739
 protein coding gene Chr5:95914456-95938318 (+)
AKR/J MGP_AKRJ_G0029685
 protein coding gene Chr5:99093546-99116241 (+)
BALB/cJ MGP_BALBcJ_G0029749
 protein coding gene Chr5:96926746-96951730 (+)
C3H/HeJ MGP_C3HHeJ_G0029472
 protein coding gene Chr5:99432809-99461640 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030204
 protein coding gene Chr5:103787764-103814810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027439
 protein coding gene Chr5:91210539-91232964 (+)
CAST/EiJ MGP_CASTEiJ_G0028883
 protein coding gene Chr5:98043699-98070900 (+)
CBA/J MGP_CBAJ_G0029442
 protein coding gene Chr5:107362394-107391458 (+)
DBA/2J MGP_DBA2J_G0029586
 protein coding gene Chr5:96109496-96132519 (+)
FVB/NJ MGP_FVBNJ_G0029545
 protein coding gene Chr5:94924811-94950019 (+)
LP/J MGP_LPJ_G0029674
 protein coding gene Chr5:100210670-100237446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029574
 protein coding gene Chr5:112441809-112467358 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030237
 protein coding gene Chr5:98531076-98557148 (+)
PWK/PhJ MGP_PWKPhJ_G0028601
 protein coding gene Chr5:94506947-94530722 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028436
 protein coding gene Chr5:96203021-96225835 (+)
WSB/EiJ MGP_WSBEiJ_G0028961
 protein coding gene Chr5:98863187-98890611 (+)



Homology
more
  • Human Ortholog
    FGF5, fibroblast growth factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF5, fibroblast growth factor 5
  • Synonyms
    HBGF-5, Smag-82, TCMGLY
  • Links
    NCBI Gene ID: 2250
    neXtProt AC: NX_P12034
    UniProt: P12034

  • Chr Location
    4q21.21; chr4:80266588-80336680 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FGF5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in significantly longer pelage hair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1180
  • Tissues
    331
  • cDNA Data
    21
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14176 NCBI Gene Model | MGI Sequence Detail 22785 C57BL/6J ±  kb
    transcript NM_010203 RefSeq | MGI Sequence Detail 2439 ZRU/MplStud  
    polypeptide P15656 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 5
      cDNA 24
      Primer pair 16
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10212, MGD-MRK-9764, MGD-MRK-9770
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 62
      Gene Ontology 6
      Phenotypes 29
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:333086 Takahashi R, et al., Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations. Int J Mol Sci. 2022 Oct 6;23(19)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory