Gene Expression Literature Summary

• Symbol: Fgf5
• Name: fibroblast growth factor 5
• ID: MGI:95519

62 matching records from 62 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3.5	E4	E4.5	E5	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)																				1				1				1
In situ RNA (section)				1				2	2	2	2	4	2	1	2	4	1	4		5	1	3		6		1		3		1		3		3
In situ RNA (whole mount)				1		1	1	5	1	3	1	5		1	1	1		2		1		1		1		1
Northern blot											1					1		1		1		2		1		1	1							2
RT-PCR	2	1	1	2	1	3		1		5		2		1	2			3	2	4	2	3	2	2	1		3	2	1	1	1	1	2	10
cDNA clones																		1									1						2	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf5  fibroblast growth factor 5   (Synonyms: Fgf-5)
Results	Reference
1	J:287755 Agarwal M, Sharma A, Kumar P, Kumar A, Bharadwaj A, Saini M, Kardon G, Mathew SJ, Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development. Development. 2020 Apr 6;147(7):dev184507
3*	J:50876 Arsenian S, Weinhold B, Oelgeschlager M, Ruther U, Nordheim A, Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 1998 Nov 2;17(21):6289-99
3*	J:67307 Bachler M, Neubuser A, Expression of members of the Fgf family and their receptors during midfacial development. Mech Dev. 2001 Feb;100(2):313-6
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
2*	J:16855 Coleman-Krnacik S, Rosen JM, Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development. Mol Endocrinol. 1994 Feb;8(2):218-29
1	J:124681 Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, Mishina Y, Rodriguez TA, BMP signalling inhibits premature neural differentiation in the mouse embryo. Development. 2007 Sep;134(18):3359-69
7*	J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74
1*	J:263987 Dobreva MP, Abon Escalona V, Lawson KA, Sanchez MN, Ponomarev LC, Pereira PNG, Stryjewska A, Criem N, Huylebroeck D, Chuva de Sousa Lopes SM, Aerts S, Zwijsen A, Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling. Development. 2018 Jul 2;145(13):dev157222
4*	J:4592 Drucker BJ, Goldfarb M, Murine FGF-4 gene expression is spatially restricted within embryonic skeletal muscle and other tissues. Mech Dev. 1993 Mar;40(3):155-63
12*	J:231094 Du W, Prochazka J, Prochazkova M, Klein OD, Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 Mar;20(2):81-7
1	J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
2*	J:83729 Goldin SN, Papaioannou VE, Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm. Genesis. 2003 May;36(1):40-7
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:217689 Guzman-Ayala M, Sachs M, Koh FM, Onodera C, Bulut-Karslioglu A, Lin CJ, Wong P, Nitta R, Song JS, Ramalho-Santos M, Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development. 2015 Jan 1;142(1):118-27
1	J:204192 Hadjab S, Franck MC, Wang Y, Sterzenbach U, Sharma A, Ernfors P, Lallemend F, A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. J Neurosci. 2013 Nov 6;33(45):17656-66
1*	J:76230 Hajihosseini MK, Heath JK, Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mech Dev. 2002 Apr;113(1):79-83
1	J:321523 Han D, Wu G, Chen R, Drexler HCA, MacCarthy CM, Kim KP, Adachi K, Gerovska D, Mavrommatis L, Bedzhov I, Arauzo-Bravo MJ, Scholer HR, A balanced Oct4 interactome is crucial for maintaining pluripotency. Sci Adv. 2022 Feb 18;8(7):eabe4375
1*	J:13172 Han JK, Martin GR, Embryonic expression of Fgf-6 is restricted to the skeletal muscle lineage. Dev Biol. 1993 Aug;158(2):549-54
15*	J:458 Haub O, Goldfarb M, Expression of the fibroblast growth factor-5 gene in the mouse embryo. Development. 1991 Jun;112(2):397-406
7*	J:20079 Hebert JM, Basilico C, Goldfarb M, Haub O, Martin GR, Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Dev Biol. 1990 Apr;138(2):454-63
6*	J:25027 Hebert JM, Boyle M, Martin GR, mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. Development. 1991 Jun;112(2):407-15
2	J:157252 Hiramatsu R, Harikae K, Tsunekawa N, Kurohmaru M, Matsuo I, Kanai Y, FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation. Development. 2010 Jan;137(2):303-12
2*	J:18126 Holdener BC, Faust C, Rosenthal NS, Magnuson T, msd is required for mesoderm induction in mice. Development. 1994 May;120(5):1335-46
3	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1	J:254969 Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J, Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. Elife. 2017 Nov 23;6:e33333
2	J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
1	J:59069 Klingensmith J, Ang SL, Bachiller D, Rossant J, Neural induction and patterning in the mouse in the absence of the node and its derivatives. Dev Biol. 1999 Dec 15;216(2):535-49
1	J:72550 Li C, Guo H, Xu X, Weinberg W, Deng CX, Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning. Dev Dyn. 2001 Nov;222(3):471-83
5*	J:204971 Li L, Liu C, Biechele S, Zhu Q, Song L, Lanner F, Jing N, Rossant J, Location of transient ectodermal progenitor potential in mouse development. Development. 2013 Nov;140(22):4533-43
1	J:270950 Lin K, Zhang S, Shi Q, Zhu M, Gao L, Xia W, Geng B, Zheng Z, Xu EY, Essential requirement of mammalian Pumilio family in embryonic development. Mol Biol Cell. 2018 Nov 26;29(24):2922-2932
2*	J:137199 Lupu F, Alves A, Anderson K, Doye V, Lacy E, Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell. 2008 Jun;14(6):831-42
3*	J:16888 Mason IJ, Fuller-Pace F, Smith R, Dickson C, FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions. Mech Dev. 1994 Jan;45(1):15-30
1	J:165252 Mesnard D, Constam DB, Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst. J Cell Biol. 2010 Oct 4;191(1):129-39
1	J:176435 Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB, The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. Genes Dev. 2011 Sep 1;25(17):1871-80
1	J:289378 Mesnard D, Guzman-Ayala M, Constam DB, Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. Development. 2006 Jul;133(13):2497-505
3	J:321503 Meuser M, Deuper L, Rudat C, Aydogdu N, Thiesler H, Zarnovican P, Hildebrandt H, Trowe MO, Kispert A, FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
2*	J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
1*	J:192269 Mukhopadhyay A, Krishnaswami SR, Cowing-Zitron C, Hung NJ, Reilly-Rhoten H, Burns J, Yu BD, Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. Dev Biol. 2013 Jan 15;373(2):373-82
1*	J:203737 Oda M, Oxley D, Dean W, Reik W, Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One. 2013;8(6):e68846
1	J:155001 Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS, Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009 Dec;29(23):6309-20
1*	J:282332 Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J, Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos. Dev Biol. 2019 Nov 15;455(2):382-392
2	J:45221 Ozawa K, Seo M, Imamura T, A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR. Brain Res Brain Res Protoc. 1997 Aug;1(3):211-6
4*	J:50598 Ozawa K, Suzuki S, Asada M, Tomooka Y, Li AJ, Yoneda A, Komi A, Imamura T, An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. J Biol Chem. 1998 Oct 30;273(44):29262-71
5*	J:35179 Ozawa K, Uruno T, Miyakawa K, Seo M, Imamura T, Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development. Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):279-88
4*	J:74514 Pelton TA, Sharma S, Schulz TC, Rathjen J, Rathjen PD, Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. J Cell Sci. 2002 Jan 15;115(Pt 2):329-39
2*	J:160766 Porntaveetus T, Oommen S, Sharpe PT, Ohazama A, Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse. Gene Expr Patterns. 2010 Jun;10(4-5):193-8
2	J:176344 Ratzka A, Baron O, Grothe C, FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system. PLoS One. 2011;6(8):e23564
1	J:90060 Sil AK, Maeda S, Sano Y, Roop DR, Karin M, IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 8;428(6983):660-4
1	J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60
2	J:119030 Spater D, Hill TP, O'sullivan RJ, Gruber M, Conner DA, Hartmann C, Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development. 2006 Aug;133(15):3039-49
1	J:144999 Su H, Trombly MI, Chen J, Wang X, Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 1;23(3):304-17
1	J:56519 Sun X, Meyers EN, Lewandoski M, Martin GR, Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 1999 Jul 15;13(14):1834-46
2	J:193313 Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A, FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013 Jan 15;27(2):169-81
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:90044 Vidrich A, Buzan JM, Ilo C, Bradley L, Skaar K, Cohn SM, Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis. Dev Dyn. 2004 May;230(1):114-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:262209 Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA, Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome. Am J Med Genet C Semin Med Genet. 2017 Dec;175(4)
3*	J:150712 Yaguchi Y, Yu T, Ahmed MU, Berry M, Mason I, Basson MA, Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development. Dev Dyn. 2009 Jun 19;238(8):2058-2072
2*	J:101025 Yaylaoglu MB, Titmus A, Visel A, Alvarez-Bolado G, Thaller C, Eichele G, Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev Dyn. 2005 Oct;234(2):371-86
1	J:270801 Zhang M, Leitch HG, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I, Esrrb Complementation Rescues Development of Nanog-Null Germ Cells. Cell Rep. 2018 Jan 9;22(2):332-339
2*	J:45775 Zhou M, Sutliff RL, Paul RJ, Lorenz JN, Hoying JB, Haudenschild CC , Yin M , Coffin JD , Kong L , Kranias EG , Luo W , Boivin GP , Duffy JJ , Pawlowski SA , Doetschman T, Fibroblast growth factor 2 control of vascular tone. Nat Med. 1998 Feb;4(2):201-7