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Fes Gene Detail
Summary
  • Symbol
    Fes
  • Name
    Fes proto-oncogene, tyrosine kinase
  • Synonyms
    c-fes
  • Feature Type
    protein coding gene
  • IDs
    MGI:95514
    NCBI Gene: 14159
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80027504-80037694 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.65 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95514
 protein coding gene Chr7:80027504-80037702 (-)
129S1/SvImJ ENSMUSG00200033224
 protein coding gene Chr7:66844331-66854015 (-)
A/J ENSMUSG00195037510
 protein coding gene Chr7:71261840-71266537 (-)
AKR/J ENSMUSG00220034730
 protein coding gene Chr7:64803854-64808549 (-)
BALB/cJ ENSMUSG00180012902
 protein coding gene Chr7:67986957-67991653 (-)
C3H/HeJ ENSMUSG00175020004
 protein coding gene Chr7:68761467-68766099 (-)
C57BL/6NJ ENSMUSG00215017903
 protein coding gene Chr7:67858806-67863442 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029905
 protein coding gene Chr7:82941984-82951990 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210023393
 protein coding gene Chr7:68612698-68617330 (-)
DBA/2J ENSMUSG00185042561
 protein coding gene Chr7:72935498-72940130 (-)
FVB/NJ ENSMUSG00205014723
 protein coding gene Chr7:68495028-68499724 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230012768
 protein coding gene Chr7:79024980-79029612 (-)
NOD/ShiLtJ ENSMUSG00190017363
 protein coding gene Chr7:68752697-68757326 (-)
NZO/HlLtJ ENSMUSG00225041739
 protein coding gene Chr7:77258857-77268603 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FES, FES proto-oncogene, tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FES, FES proto-oncogene, tyrosine kinase
  • Synonyms
    FPS
  • Links
    NCBI Gene ID: 2242
    UniProt: P07332

  • Chr Location
    15q26.1; chr15:90883695-90896213 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human FES associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show partial in utero lethality, runting, altered hematopoietic homeostasis and macrophage function, skin lesions and susceptibility to bacterial infection. Homozygotes for another null allele show enhanced LPS sensitivity, altered hematopoiesis and larger litter size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    90
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    28
  • cDNA Data
    45
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053158 Ensembl Gene Model | MGI Sequence Detail 10191 C57BL/6J ±  kb
    transcript ENSMUST00000080932 Ensembl | MGI Sequence Detail 2762 Not Applicable  
    polypeptide ENSMUSP00000079733 Ensembl | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 8
      cDNA 46
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9758, MGI:2142003, MGI:2142293
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 33
    • Earliest
      J:6419 Barbacid M, et al., Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5158-62
    • Latest
      J:369953 Laight BJ, et al., Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy. Cancer Res. 2025 Jul 15;85(14):2643-2658
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory