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Crhr2 Gene Detail
Summary
  • Symbol
    Crhr2
  • Name
    corticotropin releasing hormone receptor 2
  • Synonyms
    CRF 2 receptor, Crfr2, CRF-R2, CRFR2alpha, CRFR2beta, CRH-R2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894312
    NCBI Gene: 12922
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55067034-55110001 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.33 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1345 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894312
 protein coding gene Chr6:55067033-55110001 (-)
129S1/SvImJ ENSMUSG00200005698
 protein coding gene Chr6:52044006-52086968 (-)
A/J ENSMUSG00195032217
 protein coding gene Chr6:51781145-51824116 (-)
AKR/J ENSMUSG00220005496
 protein coding gene Chr6:51477591-51520556 (-)
BALB/cJ ENSMUSG00180009924
 protein coding gene Chr6:52075109-52118069 (-)
C3H/HeJ ENSMUSG00175034843
 protein coding gene Chr6:51836243-51879210 (-)
C57BL/6NJ ENSMUSG00215019076
 protein coding gene Chr6:52052136-52095067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028411
 protein coding gene Chr6:49565676-49609056 (-)
CAST/EiJ ENSTCUG00005038823
 protein coding gene Chr6:51311311-51354024 (-)
CBA/J ENSMUSG00210031930
 protein coding gene Chr6:51880622-51923578 (-)
DBA/2J ENSMUSG00185018381
 protein coding gene Chr6:52460164-52503130 (-)
FVB/NJ ENSMUSG00205027692
 protein coding gene Chr6:52110135-52153096 (-)
JF1/MsJ ENSUMUG00000033692
 protein coding gene Chr6:51844382-51887008 (-)
LP/J ENSMUSG00230011451
 protein coding gene Chr6:53541044-53584004 (-)
NOD/ShiLtJ ENSMUSG00190008688
 protein coding gene Chr6:51791769-51834729 (-)
NZO/HlLtJ ENSMUSG00225013424
 protein coding gene Chr6:55532653-55575612 (-)
PWK/PhJ ENSLUMG00010017002
 protein coding gene Chr6:51585212-51627937 (-)
SPRET/EiJ ENSMSPG00010008136
 protein coding gene Chr6:52188573-52230524 (-)
WSB/EiJ ENSIUOG00005019176
 protein coding gene Chr6:52143660-52186690 (-)



Homology
more
  • Human Ortholog
    CRHR2, corticotropin releasing hormone receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRHR2, corticotropin releasing hormone receptor 2
  • Synonyms
    CRF2, CRFR2, CRF-RB, HM-CRF
  • Links
    NCBI Gene ID: 1395
    UniProt: Q13324

  • Chr Location
    7p14.3; chr7:30651444-30700129 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CRHR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may result in hypersensitivity to stress, increased anxiety-like behavior, abnormal homeostatic responses to challenges of increased dietary fat and cold, and cardiovascular abnormalities, including hypertension and decreased cardiac contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    71
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003476 Ensembl Gene Model | MGI Sequence Detail 42968 C57BL/6J ±  kb
    transcript ENSMUST00000212633 Ensembl | MGI Sequence Detail 2041 Not Applicable  
    polypeptide ENSMUSP00000148408 Ensembl | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005870 corticotropin-releasing factor receptor 2
      (term hierarchy)
    • PDB
      1U34, 2JNC, 2JND
    • InterPro Domains
      IPR003051 GPCR, family 2, corticotropin releasing factor receptor
      IPR003053 GPCR, family 2, corticotropin releasing factor receptor, type 2
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q60748 5 sites
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 4
      cDNA 12
      Primer pair 9
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 61
    • Earliest
      J:24160 Perrin M, et al., Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2969-73
    • Latest
      J:378765 Wu SJ, et al., Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026 Jan 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory