Prl8a2 MGI Mouse Gene Detail - MGI:894281 - prolactin family 8, subfamily a, member 2

Symbol

Prl8a2
Name

prolactin family 8, subfamily a, member 2
Synonyms

DPRP, Dtprp, D/tPRP, mdPRP

Feature Type

protein coding gene
IDs

MGI:894281
NCBI Gene: 13529
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:27529656-27538199 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 12.41 cM
Mapping Data

8 experiments

SNPs within 2kb

311 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894281	protein coding gene	Chr13:27529656-27538199 (+)
129S1/SvImJ	ENSMUSG00200027662	protein coding gene	Chr13:24689400-24697943 (+)
A/J	ENSMUSG00195036994	protein coding gene	Chr13:23827594-23836139 (+)
AKR/J	ENSMUSG00220012522	protein coding gene	Chr13:23637134-23645675 (+)
BALB/cJ	ENSMUSG00180021000	protein coding gene	Chr13:24132845-24141390 (+)
C3H/HeJ	ENSMUSG00175030631	protein coding gene	Chr13:24155512-24164059 (+)
C57BL/6NJ	ENSMUSG00215008288	protein coding gene	Chr13:24294513-24303060 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018367	protein coding gene	Chr13:23061982-23070778 (+)
CAST/EiJ	ENSTCUG00005009784	protein coding gene	Chr13:24308591-24317168 (+)
CBA/J	ENSMUSG00210026635	protein coding gene	Chr13:24099785-24108330 (+)
DBA/2J	ENSMUSG00185019336	protein coding gene	Chr13:24921724-24930271 (+)
FVB/NJ	ENSMUSG00205023822	protein coding gene	Chr13:23918902-23927451 (+)
JF1/MsJ	ENSUMUG00000014312	protein coding gene	Chr13:24551820-24560340 (+)
LP/J	ENSMUSG00230019032	protein coding gene	Chr13:34243119-34251664 (+)
NOD/ShiLtJ	ENSMUSG00190028780	protein coding gene	Chr13:23903789-23912338 (+)
NZO/HlLtJ	ENSMUSG00225043411	protein coding gene	Chr13:28029329-28037874 (+)
PWK/PhJ	ENSLUMG00010028155	protein coding gene	Chr13:23385055-23393593 (+)
SPRET/EiJ	ENSMSPG00010021924	protein coding gene	Chr13:23338651-23346946 (+)
WSB/EiJ	ENSIUOG00005015788	protein coding gene	Chr13:23476905-23485404 (+)

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MGI Vertebrate Homology

Prl8a2 stringent orthology
1 mouse;1 rat
Gene Tree

Prl8a2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Prl8a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced pregnancy success when exposed to hypoxic conditions.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

671
Tissues

29
cDNA Data

121
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

4
UniProt

5
CCDS

CCDS26396.1, CCDS70440.1

Ensembl

ENSMUSG00000018259 (Evidence)
NCBI Gene

13529

			Length	Strain/Species	Flank
genomic	13529	NCBI Gene Model \| MGI Sequence Detail	8544	C57BL/6J	± kb
transcript	NM_010088	RefSeq \| MGI Sequence Detail	939	ZRU/MplStud
polypeptide	NP_034218	RefSeq \| MGI Sequence Detail	240	ZRU/MplStud

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UniProt

5 Sequences
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR001400 Somatotropin/prolactin

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All nucleic 129

Genomic 1

cDNA 122

Primer pair 5

Other 1

Antibodies 1

Microarray probesets 4

Summaries

All 66

Developmental Gene Expression 18

Gene Ontology 4

Phenotypes 16
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:337679 Sirohi VK, et al., Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss. iScience. 2023 Jul 21;26(7):107028

TSS for Prl8a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119035	Chr13:27529644-27529662 (+)	-3 bp
Tssr119036	Chr13:27529667-27529668 (+)	12 bp
Tssr119037	Chr13:27529677-27529684 (+)	25 bp
Tssr119038	Chr13:27532855-27532864 (+)	3,204 bp
Tssr119039	Chr13:27532990-27532996 (+)	3,337 bp
Tssr119040	Chr13:27538097-27538103 (+)	8,444 bp
Tssr119041	Chr13:27538109-27538114 (+)	8,456 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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