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Xrn1 Gene Detail
Summary
  • Symbol
    Xrn1
  • Name
    5'-3' exoribonuclease 1
  • Synonyms
    Dhm2, mXrn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891964
    NCBI Gene: 24127
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95836813-95939856 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 50.31 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891964
 protein coding gene Chr9:95836803-95939859 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035140
 protein coding gene Chr9:97113654-97221061 (+)
A/J MGP_AJ_G0035121
 protein coding gene Chr9:93740191-93842477 (+)
AKR/J MGP_AKRJ_G0035053
 protein coding gene Chr9:96010573-96120811 (+)
BALB/cJ MGP_BALBcJ_G0035114
 protein coding gene Chr9:93424497-93527787 (+)
C3H/HeJ MGP_C3HHeJ_G0034824
 protein coding gene Chr9:96438910-96544703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035634
 protein coding gene Chr9:99897536-100005938 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032535
 protein coding gene Chr9:91557591-91664865 (+)
CAST/EiJ MGP_CASTEiJ_G0034136
 protein coding gene Chr9:96171784-96284762 (+)
CBA/J MGP_CBAJ_G0034792
 protein coding gene Chr9:103365281-103479819 (+)
DBA/2J MGP_DBA2J_G0034954
 protein coding gene Chr9:93262448-93368687 (+)
FVB/NJ MGP_FVBNJ_G0034902
 protein coding gene Chr9:92106673-92211940 (+)
LP/J MGP_LPJ_G0035033
 protein coding gene Chr9:97371937-97499779 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034941
 protein coding gene Chr9:105366400-105474229 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035656
 protein coding gene Chr9:96237626-96350158 (+)
PWK/PhJ MGP_PWKPhJ_G0033843
 protein coding gene Chr9:93419561-93526259 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033678
 protein coding gene Chr9:96248563-96357727 (+)
WSB/EiJ MGP_WSBEiJ_G0034256
 protein coding gene Chr9:96109478-96218096 (+)



Homology
more
  • Human Ortholog
    XRN1, 5'-3' exoribonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XRN1, 5'-3' exoribonuclease 1
  • Synonyms
    SEP1
  • Links
    NCBI Gene ID: 54464
    neXtProt AC: NX_Q8IZH2
    UniProt: Q8IZH2

  • Chr Location
    3q23; chr3:142306607-142448062 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human XRN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    28
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032410 Ensembl Gene Model | MGI Sequence Detail 103044 C57BL/6J ±  kb
transcript ENSMUST00000034981 Ensembl | MGI Sequence Detail 5499 Not Applicable  
polypeptide ENSMUSP00000034981 Ensembl | MGI Sequence Detail 1723 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:39219 Bashkirov VI, et al., A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J Cell Biol. 1997 Feb 24;136(4):761-73
  • Latest
    J:328765 Li L, et al., The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m(6)A recognition. Mol Cell. 2022 May 5;82(9):1678-1690.e12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory