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Cyp2a4 Gene Detail
Summary
  • Symbol
    Cyp2a4
  • Name
    cytochrome P450, family 2, subfamily a, polypeptide 4
  • Synonyms
    Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88596
    NCBI Gene: 13086
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26006617-26014513 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    11
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88596
 protein coding gene Chr7:26006594-26014513 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031871
 protein coding gene Chr7:24810860-24965337 (+)
AKR/J MGP_AKRJ_G0031801
 protein coding gene Chr7:25429390-25452377 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0031591
 protein coding gene Chr7:25258109-25288415 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032340
 protein coding gene Chr7:26283310-26309038 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029395
 protein coding gene Chr7:26094404-26102261 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031556
 protein coding gene Chr7:26658970-26704017 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031663
 protein coding gene Chr7:24171107-24201418 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031706
 protein coding gene Chr7:26952813-26963925 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030491
 protein coding gene Chr7:16137463-16145273 (+)
WSB/EiJ MGP_WSBEiJ_G0031041
 protein coding gene Chr7:25291597-25319804 (+)



Homology
more
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
  • Synonyms
    CPAD, CYP2A, CYPIIA13
  • Links
    NCBI Gene ID: 1553
    neXtProt AC: NX_Q16696
    UniProt: Q16696

  • Chr Location
    19q13.2; chr19:41088451-41096195 (+)  GRCh38
  • Human Ortholog
    CYP2A6, cytochrome P450 family 2 subfamily A member 6
  • Synonyms
    CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
  • Links
    NCBI Gene ID: 1548
    neXtProt AC: NX_P11509
    UniProt: P11509

  • Chr Location
    19q13.2; chr19:40843541-40850447 (-)  GRCh38
  • Human Ortholog
    CYP2A7, cytochrome P450 family 2 subfamily A member 7
  • Synonyms
    CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
  • Links
    NCBI Gene ID: 1549
    neXtProt AC: NX_P20853
    UniProt: P20853

  • Chr Location
    19q13.2; chr19:40875439-40882752 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    107
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13086 NCBI Gene Model | MGI Sequence Detail 7897 C57BL/6J ±  kb
transcript NM_009997 RefSeq | MGI Sequence Detail 1715 FVB/N  
polypeptide P15392 UniProt | EBI | MGI Sequence Detail 494 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 17
    Genomic 4
    cDNA 11
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-18618, MGD-MRK-2298, MGD-MRK-2313, MGI:101806, MGI:2142076
References
more
  • Summaries
    All 47
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:30977 Burkhart BA, et al., Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. J Biol Chem. 1985 Dec 5;260(28):15357-61
  • Latest
    J:342868 Oguro A, et al., Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder. J Lipid Res. 2023 Nov;64(11):100458
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory