Cd24a MGI Mouse Gene Detail - MGI:88323

Symbol

Cd24a
Name

CD24a antigen
Synonyms

cluster of differentiation 24, heat stable antigen, HSA, Ly-52, nectadrin

Feature Type

protein coding gene
IDs

MGI:88323
NCBI Gene: 12484
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:43454433-43460261 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 23.01 cM
Mapping Data

4 experiments

SNPs within 2kb

74 from dbSNP Build 142
Strain Annotations

16
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88323	protein coding gene	Chr10:43454280-43460261 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017195	protein coding gene	Chr10:42363170-42368264 (+)
A/J	MGP_AJ_G0017173	protein coding gene	Chr10:41182841-41188155 (+)
AKR/J	MGP_AKRJ_G0017133	protein coding gene	Chr10:41799972-41805085 (+)
BALB/cJ	MGP_BALBcJ_G0017134	protein coding gene	Chr10:41222973-41228060 (+)
C3H/HeJ	MGP_C3HHeJ_G0016955	protein coding gene	Chr10:42151967-42157064 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017594	protein coding gene	Chr10:43669584-43674675 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015289	protein coding gene	Chr10:39125446-39130863 (+)
CAST/EiJ	MGP_CASTEiJ_G0016534	protein coding gene	Chr10:42380765-42386210 (+)
CBA/J	MGP_CBAJ_G0016929	protein coding gene	Chr10:45646644-45651735 (+)
DBA/2J	MGP_DBA2J_G0017035	protein coding gene	Chr10:40638514-40643591 (+)
FVB/NJ	MGP_FVBNJ_G0017030	protein coding gene	Chr10:40133892-40138985 (+)
LP/J	MGP_LPJ_G0017111	protein coding gene	Chr10:42377497-42382812 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017059	protein coding gene	Chr10:46361181-46368900 (+)
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0016098	protein coding gene	Chr10:41653543-41658424 (+)
WSB/EiJ	MGP_WSBEiJ_G0016597	protein coding gene	Chr10:42089307-42094386 (+)

Human Ortholog

CD24, CD24 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD24, CD24 molecule
Synonyms

CD24A
Links

HGNC:1645

NCBI Gene ID: 100133941

neXtProt AC: NX_P25063

UniProt: P25063
Chr Location

chr6:106969831-106976855 (-) GRCh38

MGI Vertebrate Homology

Cd24a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD24
Gene Tree

Cd24a

Diseases

1 with human CD24 associations

				Human Disease	Mouse Models
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cd24a
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in slight impairment of B cell development. Mutant erythrocytes have increased tendency to aggregate.

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All GO Annotations

129
GO References

68

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1058
Tissues

269
cDNA Data

459
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

6
UniProt

4
CCDS

CCDS23821.1

Ensembl

ENSMUSG00000047139 (Evidence)
NCBI Gene

12484

			Length	Strain/Species	Flank
genomic	12484	NCBI Gene Model \| MGI Sequence Detail	5829	C57BL/6J	± kb
transcript	NM_001428380	RefSeq \| MGI Sequence Detail	1884	C57BL/6
polypeptide	P24807	UniProt \| EBI \| MGI Sequence Detail	76	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001932 signal transducer CD24

(term hierarchy)
InterPro Domains

IPR028029 Signal transducer CD24

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All nucleic 469

Genomic 2

cDNA 462

Primer pair 3

Other 2

Microarray probesets 4

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MGD-MRK-11995, MGD-MRK-1840

Summaries

All 178

Developmental Gene Expression 35

Gene Ontology 68

Phenotypes 48
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:335545 Dror E, et al., Epigenetic dosage identifies two major and functionally distinct beta cell subtypes. Cell Metab. 2023 May 2;35(5):821-836.e7

TSS for Cd24a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93141	Chr10:43455157-43455174 (+)	733 bp
Tssr93142	Chr10:43455919-43455941 (+)	1,497 bp
Tssr93143	Chr10:43458685-43458727 (+)	4,273 bp
Tssr93144	Chr10:43459892-43459896 (+)	5,461 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23