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Ccnd1 Gene Detail
Summary
  • Symbol
    Ccnd1
  • Name
    cyclin D1
  • Synonyms
    bcl-1, cD1, CycD1, Cyl-1, PRAD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88313
    NCBI Gene: 12443
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144483668-144493568 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.92 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88313
protein coding gene Chr7:144483668-144493662 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033295
protein coding gene Chr7:150309463-150319401 (-)
A/J MGP_AJ_G0033278
protein coding gene Chr7:145956641-145966578 (-)
AKR/J MGP_AKRJ_G0033209
protein coding gene Chr7:150051379-150061320 (-)
BALB/cJ MGP_BALBcJ_G0033278
protein coding gene Chr7:145720153-145730078 (-)
C3H/HeJ MGP_C3HHeJ_G0032992
protein coding gene Chr7:149825193-149835157 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033788
protein coding gene Chr7:155727809-155737748 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030761
protein coding gene Chr7:147107578-147117585 (-)
CAST/EiJ MGP_CASTEiJ_G0032314
protein coding gene Chr7:142109122-142143769 (-)
CBA/J MGP_CBAJ_G0032965
protein coding gene Chr7:161023425-161033368 (-)
DBA/2J MGP_DBA2J_G0033119
protein coding gene Chr7:143920064-143929986 (-)
FVB/NJ MGP_FVBNJ_G0033067
protein coding gene Chr7:143861849-143871785 (-)
LP/J MGP_LPJ_G0033211
protein coding gene Chr7:151851944-151861827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033101
protein coding gene Chr7:161553811-161563745 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033806
protein coding gene Chr7:149019756-149029686 (-)
PWK/PhJ MGP_PWKPhJ_G0032024
protein coding gene Chr7:137210346-137249421 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031868
protein coding gene Chr7:135784033-135821206 (-)
WSB/EiJ MGP_WSBEiJ_G0032428
protein coding gene Chr7:150010896-150020830 (-)



Homology
more
  • Human Ortholog
    CCND1, cyclin D1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCND1, cyclin D1
  • Synonyms
    BCL1, D11S287E, PRAD1, U21B31
  • Links
    NCBI Gene ID: 595
    neXtProt AC: NX_P24385
    UniProt: P24385

  • Chr Location
    11q13.3; chr11:69641156-69654474 (+)  GRCh38

Human Diseases
more
  • Diseases
    17 with human CCND1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 11 alleles in 14 genetic backgrounds
    53 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations may exhibit reduced body size and viability, impaired retinal development, pregnancy-insensitive mammary glands, and modified development of mammary cancer induced by neu and ras oncogenes, depending on the specific allele or genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12443 NCBI Gene Model | MGI Sequence Detail 9901 C57BL/6J ±  kb
    transcript NM_001379248 RefSeq | MGI Sequence Detail 3768 ZRU/MplStud  
    polypeptide P25322 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 9
      cDNA 32
      Primer pair 22
      Other 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1825, MGI:2141923
    References
    more
    • Summaries
      All 861
      Developmental Gene Expression 572
      Gene Ontology 40
      Phenotypes 92
    • Earliest
      J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
    • Latest
      J:346597 Seo S, et al., Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/02/2024
    MGI 6.13
    The Jackson Laboratory