Bsg MGI Mouse Gene Detail - MGI:88208 - basigin

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Bsg Gene Detail

Symbol

Bsg
Name

basigin
Synonyms

5A11/Basigin, CD147, EMMPRIN, gp 42, HT-7, neurothelin

Feature Type

protein coding gene
IDs

MGI:88208
NCBI Gene: 12215
Alliance

gene page
Transcription Start Sites

9 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr10:79540325-79547803 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

12 experiments

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SNPs within 2kb

275 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_88208	protein coding gene	Chr10:79540192-79547813 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017454	protein coding gene	Chr10:80246606-80254083 (+)
A/J	MGP_AJ_G0017432	protein coding gene	Chr10:77457129-77464634 (+)
AKR/J	MGP_AKRJ_G0017393	protein coding gene	Chr10:79561521-79569002 (+)
BALB/cJ	MGP_BALBcJ_G0017394	protein coding gene	Chr10:77683472-77690990 (+)
C3H/HeJ	MGP_C3HHeJ_G0017217	protein coding gene	Chr10:79671442-79678956 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017848	protein coding gene	Chr10:83021517-83028994 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015536	protein coding gene	Chr10:73683513-73691111 (+)
CAST/EiJ	MGP_CASTEiJ_G0016784	protein coding gene	Chr10:79844640-79852106 (+)
CBA/J	MGP_CBAJ_G0017189	protein coding gene	Chr10:86243288-86250765 (+)
DBA/2J	MGP_DBA2J_G0017295	protein coding gene	Chr10:76673110-76680587 (+)
FVB/NJ	MGP_FVBNJ_G0017289	protein coding gene	Chr10:75834968-75842445 (+)
LP/J	MGP_LPJ_G0017366	protein coding gene	Chr10:80726067-80733544 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017315	protein coding gene	Chr10:88221533-88229038 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017889	protein coding gene	Chr10:79540324-79547801 (+)
PWK/PhJ	MGP_PWKPhJ_G0016565	protein coding gene	Chr10:76530330-76537936 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016354	protein coding gene	Chr10:78514153-78521629 (+)
WSB/EiJ	MGP_WSBEiJ_G0016844	protein coding gene	Chr10:79572635-79580208 (+)

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Human Ortholog

BSG, basigin (Ok blood group)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BSG, basigin (Ok blood group)
Synonyms

5F7, CD147, EMMPRIN, EMPRIN, HAb18G, OK, TCSF
Links

HGNC:1116

NCBI Gene ID: 682

UniProt: P35613
Chr Location

19p13.3; chr19:571277-583494 (+) GRCh38

MGI Vertebrate Homology

Bsg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BSG
Gene Tree

Bsg

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Phenotype Summary

58 phenotypes from 3 alleles in 5 genetic backgrounds
51 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

3
Targeted

8
Genomic Mutations

1 involving Bsg
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most homozygous null mutants die around the time of implantation. Half of the survivors die prior to 1 month of age from interstitial pneumonia. The remaining mice are small, sterile, have retinal abnormalities, and perform poorly in behavioral tests.

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All GO Annotations

72
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1206
Tissues

289
cDNA Data

495
Literature Summary

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bsg

ZFIN bsg

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All Sequences

69
RefSeq

4
UniProt

5
CCDS

CCDS23985.1, CCDS35967.1

Ensembl

ENSMUSG00000023175 (Evidence)
NCBI Gene

12215

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000023175	Ensembl Gene Model \| MGI Sequence Detail	7479	C57BL/6J	± kb
	transcript	ENSMUST00000067036	Ensembl \| MGI Sequence Detail	1526	Not Applicable
	polypeptide	ENSMUSP00000070751	Ensembl \| MGI Sequence Detail	389	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001324 basigin

(term hierarchy)
PDB

7Y1B, 7Y1Q
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2
GlyGen

P18572 4 sites, 10 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 510

Genomic 3

cDNA 495

Primer pair 9

Other 3

Microarray probesets 2

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MGD-MRK-1674, MGI:2143523, MGI:2143580

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Summaries

All 145

Developmental Gene Expression 17

Gene Ontology 17

Phenotypes 51
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:365408 Lv JJ, et al., CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis. Circ Res. 2024 Jan 19;134(2):165-185

TSS for Bsg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94376	Chr10:79540312-79540330 (+)	-4 bp
Tssr94377	Chr10:79540333-79540346 (+)	15 bp
Tssr94378	Chr10:79545911-79545934 (+)	5,598 bp
Tssr3273	Chr10:79545947-79545953 (+)	5,625 bp
Tssr94379	Chr10:79546089-79546101 (+)	5,770 bp
Tssr94380	Chr10:79546601-79546625 (+)	6,288 bp
Tssr94381	Chr10:79546635-79546702 (+)	6,344 bp
Tssr94382	Chr10:79546724-79546734 (+)	6,404 bp
Tssr94383	Chr10:79547410-79547509 (+)	7,135 bp

Bsg is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cia8	Chr10, 38.48 cM	Chr10:51493400-82491121	J:81372	Microarray gene expression analysis was used to identify candidate genes for QTLs associated with collagen-induced arthritis. RNA from inflamed paws of collagen-treated mice were used in the microarray analysis and compared to RNA from normal paws. 223 genes showed a four-fold or greater expression difference between inflamed and normal paws. Nine of these genes are located near previously identified arthritis severity/susceptibility QTLs and may be considered for candidates. For Cia1 on mouse Chromosome 17 (18.6 cM near the H2 locus) differential expression was observed for H2-Eb1 (18.66 cM) and H2-T23 (19.73 cM). For Cia2 and Cia4 on mouse Chromosome 2 (both are located at 34 cM) differential expression was observed for Fap (36 cM) and Gcg (36 cM). For Cia3 (48.7 cM) and Cia6 (30 cM) on mouse Chromosome 6 differential expression was observed for Raf1 (52.5 cM) and Slc6a6 (38.2 cM), respectively. For Cia5 (40 cM) on mouse Chromosome 4 differential expression was observed for Ctsk (47.9 cM) and Cd53(50.5 cM). For Cia8 (40.4 cM) on mouse Chromosome 10 differential expression was observed for Bsg (42.4 cM).

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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