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Glb1 Gene Detail
Summary
  • Symbol
    Glb1
  • Name
    galactosidase, beta 1
  • Synonyms
    Bge, Bgl, Bgl-e, Bgl-s, Bgl-t, Bgs, Bgt, C130097A14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88151
    NCBI Gene: 12091
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114230146-114303447 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.40 cM
  • Mapping Data
    47 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2366 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88151
 protein coding gene Chr9:114230144-114303966 (+)
129S1/SvImJ ENSMUSG00200029640
 protein coding gene Chr9:111327159-111406540 (+)
A/J ENSMUSG00195031960
 protein coding gene Chr9:110532053-110606123 (+)
AKR/J ENSMUSG00220022942
 protein coding gene Chr9:110989356-111068748 (+)
BALB/cJ ENSMUSG00180025321
 protein coding gene Chr9:111069744-111143819 (+)
C3H/HeJ ENSMUSG00175016580
 protein coding gene Chr9:111290811-111364878 (+)
C57BL/6NJ ENSMUSG00215039615
 protein coding gene Chr9:111175111-111248952 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032768
 protein coding gene Chr9:109861925-109933675 (+)
CAST/EiJ ENSTCUG00005027740
 protein coding gene Chr9:110950299-111024426 (+)
CBA/J ENSMUSG00210030323
 protein coding gene Chr9:111012018-111091392 (+)
DBA/2J ENSMUSG00185014242
 protein coding gene Chr9:111348771-111428141 (+)
FVB/NJ ENSMUSG00205042346
 protein coding gene Chr9:111192494-111266540 (+)
JF1/MsJ ENSUMUG00000044319
 protein coding gene Chr9:111179552-111252939 (+)
LP/J ENSMUSG00230048524
 protein coding gene Chr9:111455928-111535304 (+)
NOD/ShiLtJ ENSMUSG00190047675
 protein coding gene Chr9:110941896-111021276 (+)
NZO/HlLtJ ENSMUSG00225023859
 protein coding gene Chr9:111737469-111816848 (+)
PWK/PhJ ENSLUMG00010029474
 protein coding gene Chr9:111129841-111203022 (+)
SPRET/EiJ ENSMSPG00010019728
 protein coding gene Chr9:112794477-112862479 (+)
WSB/EiJ ENSIUOG00005044803
 protein coding gene Chr9:110407391-110481424 (+)



Homology
more
  • Human Ortholog
    GLB1, galactosidase beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLB1, galactosidase beta 1
  • Synonyms
    EBP, ELNR1, MPS4B
  • Links
    NCBI Gene ID: 2720
    UniProt: P16278

  • Chr Location
    3p22.3; chr3:32961108-33097202 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Glb1 mouse models; 6 with human GLB1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit progressive spastic diplegia, emaciation, and accumulation of ganglioside GM1 and asialo GM1 in brain tissue. Mutants die at 7-10 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Tissues
    103
  • cDNA Data
    13
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12091 NCBI Gene Model | MGI Sequence Detail 73302 C57BL/6J ±  kb
    transcript NM_009752 RefSeq | MGI Sequence Detail 2396 ZRU/MplStud  
    polypeptide P23780 UniProt | EBI | MGI Sequence Detail 647 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 4
      cDNA 18
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1545, MGD-MRK-1546, MGD-MRK-1547, MGD-MRK-1548, MGD-MRK-1549, MGD-MRK-1556, MGD-MRK-1557, MGI:2143293, MGI:88152, MGI:88153, MGI:88154
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 11
      Diseases 4
      Gene Ontology 18
      Phenotypes 46
    • Earliest
      J:5404 Lundin LG, et al., Mendelian inheritance of variations in beta-galactosidase activities in the house mouse. Biochem Genet. 1973 Dec;10(4):351-61
    • Latest
      J:386422 Nuzzolillo F, et al., Combined Transcriptomic and Proteomic Profiling Uncovers Developmental Dynamics of Autophagy in the Cortex. Biomedicines. 2026 Apr 2;14(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory