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Phenotypes Associated with This Genotype
Genotype
MGI:3581423
Allelic
Composition
Glb1tm1Adz/Glb1tm1Adz
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glb1tm1Adz mutation (2 available); any Glb1 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased total ganglioside content in the cerebellum and cerebrum-brainstem
• N-butyldeoxygalacto-nojirimycin (NB-DGJ), an imino sugar that inhibits ganglioside biosynthesis, significantly reduced total ganglioside and GM1 content when administered from P9-P15
• increased total ganglioside content in the cerebellum and cerebrum-brainstem
• N-butyldeoxygalacto-nojirimycin (NB-DGJ), an imino sugar that inhibits ganglioside biosynthesis, significantly reduced total ganglioside and GM1 content when administered from P9-P15

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
GM1 gangliosidosis DOID:3322 J:98543


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory