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Adrb3 Gene Detail
Summary
  • Symbol
    Adrb3
  • Name
    adrenergic receptor, beta 3
  • Synonyms
    Adrb-3, beta3-adrenergic receptor, Beta-3 adrenoceptor, beta 3-AR, Beta-3 AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87939
    NCBI Gene: 11556
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27715804-27720833 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 15.94 cM, cytoband A2-A4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87939
 protein coding gene Chr8:27715804-27740644 (-)
129S1/SvImJ ENSMUSG00200020705
 protein coding gene Chr8:22805625-22809437 (-)
A/J ENSMUSG00195005253
 protein coding gene Chr8:23314204-23318016 (-)
AKR/J ENSMUSG00220024898
 protein coding gene Chr8:22954838-22958655 (-)
BALB/cJ ENSMUSG00180005288
 protein coding gene Chr8:22838797-22842609 (-)
C3H/HeJ ENSMUSG00175006632
 protein coding gene Chr8:22917337-22921154 (-)
C57BL/6NJ ENSMUSG00215011104
 protein coding gene Chr8:22803058-22806870 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030947
 protein coding gene Chr8:21698659-21702516 (-)
CAST/EiJ ENSTCUG00005020696
 protein coding gene Chr8:23104786-23108602 (-)
CBA/J ENSMUSG00210014005
 protein coding gene Chr8:22837838-22841650 (-)
DBA/2J ENSMUSG00185033825
 protein coding gene Chr8:28656923-28660740 (-)
FVB/NJ ENSMUSG00205003317
 protein coding gene Chr8:22343470-22347282 (-)
JF1/MsJ ENSUMUG00000006255
 protein coding gene Chr8:30511303-30515117 (-)
LP/J ENSMUSG00230015143
 protein coding gene Chr8:32397993-32401805 (-)
NOD/ShiLtJ ENSMUSG00190003996
 protein coding gene Chr8:22881220-22885032 (-)
NZO/HlLtJ ENSMUSG00225019388
 protein coding gene Chr8:36030488-36034305 (-)
PWK/PhJ ENSLUMG00010025615
 protein coding gene Chr8:22890452-22894272 (-)
SPRET/EiJ ENSMSPG00010016210
 protein coding gene Chr8:23184306-23186353 (-)
WSB/EiJ ENSIUOG00005009042
 protein coding gene Chr8:23562948-23566774 (-)



Homology
more
  • Human Ortholog
    ADRB3, adrenoceptor beta 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRB3, adrenoceptor beta 3
  • Synonyms
    BETA3AR
  • Links
    NCBI Gene ID: 155
    UniProt: P13945

  • Chr Location
    8p11.23; chr8:37962990-37966599 (-)  GRCh38
Human Diseases
more
  • Diseases
    11 with human ADRB3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations develop greater adiposity, especially on a high-fat diet, and are unresponsive to the beta3-adrenergic receptor agonist, CL316,243.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    34
  • cDNA Data
    13
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11556 NCBI Gene Model | MGI Sequence Detail 5030 C57BL/6J ±  kb
    transcript NM_013462 RefSeq | MGI Sequence Detail 2113 C57BL/6  
    polypeptide P25962 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 6
      cDNA 13
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1145, MGD-MRK-1148
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 15
      Phenotypes 102
    • Earliest
      J:1532 Nahmias C, et al., Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 1991 Dec;10(12):3721-7
    • Latest
      J:381213 Elmendorf AJ, et al., GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice. Mol Metab. 2026 Mar;105:102328
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory