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Chrna5 Gene Detail
Summary
  • Symbol
    Chrna5
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 5
  • Synonyms
    Acra-5, Acra5
  • Feature Type
    protein coding gene
  • IDs
    MGI:87889
    NCBI Gene: 110835
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54888164-54915063 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.84 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    779 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87889
 protein coding gene Chr9:54888112-54918704 (+)
129S1/SvImJ ENSMUSG00200031901
 protein coding gene Chr9:52015052-52041965 (+)
A/J ENSMUSG00195034424
 protein coding gene Chr9:51713736-51740638 (+)
AKR/J ENSMUSG00220024864
 protein coding gene Chr9:51846675-51873572 (+)
BALB/cJ ENSMUSG00180016512
 protein coding gene Chr9:51827122-51854022 (+)
C3H/HeJ ENSMUSG00175020789
 protein coding gene Chr9:51838912-51865809 (+)
C57BL/6NJ ENSMUSG00215025192
 protein coding gene Chr9:51812259-51839161 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032239
 protein coding gene Chr9:51734970-51762250 (+)
CAST/EiJ ENSTCUG00005020959
 protein coding gene Chr9:51748322-51774555 (+)
CBA/J ENSMUSG00210034821
 protein coding gene Chr9:51941480-51968411 (+)
DBA/2J ENSMUSG00185038824
 protein coding gene Chr9:51970998-51997918 (+)
FVB/NJ ENSMUSG00205036617
 protein coding gene Chr9:52251466-52278394 (+)
JF1/MsJ ENSUMUG00000026694
 protein coding gene Chr9:51977336-52004450 (+)
LP/J ENSMUSG00230035083
 protein coding gene Chr9:52215022-52241943 (+)
NOD/ShiLtJ ENSMUSG00190039150
 protein coding gene Chr9:52029269-52056169 (+)
NZO/HlLtJ ENSMUSG00225026727
 protein coding gene Chr9:52237010-52263939 (+)
PWK/PhJ ENSLUMG00010038329
 protein coding gene Chr9:51940457-51967492 (+)
SPRET/EiJ ENSMSPG00010022985
 protein coding gene Chr9:52945976-52973027 (+)
WSB/EiJ ENSIUOG00005037252
 protein coding gene Chr9:51439644-51466597 (+)



Homology
more
  • Human Ortholog
    CHRNA5, cholinergic receptor nicotinic alpha 5 subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNA5, cholinergic receptor nicotinic alpha 5 subunit
  • Synonyms
    LNCR2
  • Links
    NCBI Gene ID: 1138
    UniProt: P30532

  • Chr Location
    15q25.1; chr15:78565520-78595269 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human CHRNA5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are less sensitive to nicotine-induced seizures and exhibit a significantly shorter latency time to seizure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    66
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    60
  • cDNA Data
    16
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035594 Ensembl Gene Model | MGI Sequence Detail 26900 C57BL/6J ±  kb
transcript ENSMUST00000213960 Ensembl | MGI Sequence Detail 1737 Not Applicable  
polypeptide ENSMUSP00000150942 Ensembl | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005458 neuronal acetylcholine receptor subunit alpha-5
    (term hierarchy)
  • InterPro Domains
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    IPR002394 Nicotinic acetylcholine receptor
  • GlyGen
    Q2MKA5 3 sites
Molecular
Reagents
less
  • All nucleic 22
    cDNA 18
    Primer pair 3
    Other 1
    Antibodies 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-1058, MGD-MRK-1062
References
more
  • Summaries
    All 105
    Developmental Gene Expression 10
    Gene Ontology 13
    Phenotypes 49
  • Earliest
    J:11050 Eng CM, et al., Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. Genomics. 1991 Feb;9(2):278-82
  • Latest
    J:374551 Koukouli F, et al., The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology. Mol Psychiatry. 2026 Mar;31(3):1293-1310
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory