About   Help   FAQ
Apol11a Gene Detail
Summary
  • Symbol
    Apol11a
  • Name
    apolipoprotein L 11a
  • Synonyms
    EG626615
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649094
    NCBI Gene: 626615
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77392329-77402074 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649094
 protein coding gene Chr15:77392329-77402251 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0022432
 protein coding gene Chr15:80602680-80631377 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019968
 protein coding gene Chr15:71630976-71640168 (-)
CAST/EiJ MGP_CASTEiJ_G0021286
 protein coding gene Chr15:77669929-77710556 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0021856
 protein coding gene Chr15:74463934-74525980 (-)
FVB/NJ MGP_FVBNJ_G0021838
 protein coding gene Chr15:73408402-73414142 (+)
LP/J MGP_LPJ_G0021930
 protein coding gene Chr15:77908319-77912349 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021030
 protein coding gene Chr15:74498957-74507995 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    APOL1, apolipoprotein L1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOL1, apolipoprotein L1
  • Synonyms
    APOL, APO-L, APOL-I, FSGS4
  • Links
    NCBI Gene ID: 8542
    neXtProt AC: NX_O14791
    UniProt: O14791

  • Chr Location
    22q12.3; chr22:36253071-36267530 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human APOL2,APOL4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    2
  • Radiation induced
    2
  • Genomic Mutations
    4 involving Apol11a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 626615 NCBI Gene Model | MGI Sequence Detail 9746 C57BL/6J ±  kb
transcript NM_001177533 RefSeq | MGI Sequence Detail 1134 C57BL/6  
polypeptide NP_001171004 RefSeq | MGI Sequence Detail 334 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR008405 Apolipoprotein L
References
more
  • Summaries
    All 30
    Diseases 1
    Gene Ontology 2
    Phenotypes 21
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory