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Morc2b Gene Detail
Summary
  • Symbol
    Morc2b
  • Name
    microrchidia 2B
  • Synonyms
    4932411A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045293
    NCBI Gene: 240069
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33354562-33369473 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045293
 protein coding gene Chr17:33332325-33369473 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023522
 protein coding gene Chr17:33036950-33041043 (-)
A/J MGP_AJ_G0023480
 protein coding gene Chr17:31937789-31941880 (-)
AKR/J MGP_AKRJ_G0023446
 protein coding gene Chr17:32249027-32253118 (-)
BALB/cJ MGP_BALBcJ_G0023485
 protein coding gene Chr17:32038169-32042267 (-)
C3H/HeJ MGP_C3HHeJ_G0023248
 protein coding gene Chr17:32638140-32642227 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023928
 protein coding gene Chr17:34160172-34164265 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021402
 protein coding gene Chr17:29496982-29501088 (-)
CAST/EiJ MGP_CASTEiJ_G0022748
 protein coding gene Chr17:32745536-32749622 (-)
CBA/J MGP_CBAJ_G0023221
 protein coding gene Chr17:35671548-35675631 (-)
DBA/2J MGP_DBA2J_G0023351
 protein coding gene Chr17:31310906-31315017 (-)
FVB/NJ MGP_FVBNJ_G0023321
 protein coding gene Chr17:31119553-31123645 (-)
LP/J MGP_LPJ_G0023430
 protein coding gene Chr17:33257957-33262058 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023340
 protein coding gene Chr17:34662523-34666615 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023970
 protein coding gene Chr17:32618520-32622621 (-)
PWK/PhJ MGP_PWKPhJ_G0022495
 protein coding gene Chr17:30235491-30239648 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022315
 protein coding gene Chr17:30586656-30590748 (-)
WSB/EiJ MGP_WSBEiJ_G0022809
 protein coding gene Chr17:32623976-32628066 (-)



Homology
more
  • Human Ortholog
    MORC2, MORC family CW-type zinc finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MORC2, MORC family CW-type zinc finger 2
  • Synonyms
    CMT2Z, DIGFAN, ZCW3, ZCWCC1
  • Links
    NCBI Gene ID: 22880
    neXtProt AC: NX_Q9Y6X9
    UniProt: Q9Y6X9

  • Chr Location
    22q12.2; chr22:30925130-30968774 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MORC2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display male and female infertility with failure of chromosomal synapsis, double strand break repair, and recombination in meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    23
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240069 NCBI Gene Model | MGI Sequence Detail 14912 C57BL/6J ±  kb
    transcript NM_001360203 RefSeq | MGI Sequence Detail 3953 C57BL/6  
    polypeptide Q8C5W4 UniProt | EBI | MGI Sequence Detail 1022 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 1
    • Earliest
      J:102875 Hayashi K, et al., A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature. 2005 Nov 17;438(7066):374-8
    • Latest
      J:256987 Shi B, et al., MORC2B is essential for meiotic progression and fertility. PLoS Genet. 2018 Jan;14(1):e1007175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory