About   Help   FAQ
Fhip2b Gene Detail
Summary
  • Symbol
    Fhip2b
  • Name
    FHF complex subunit HOOK interacting protein 2B
  • Synonyms
    Fam160b2, G430067P06Rik, Rai16
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036290
    NCBI Gene: 239170
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70820736-70837275 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    424 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036290
 protein coding gene Chr14:70820733-70837309 (-)
129S1/SvImJ ENSMUSG00200026265
 protein coding gene Chr14:59213714-59230218 (-)
A/J ENSMUSG00195013851
 protein coding gene Chr14:59393637-59410142 (-)
AKR/J ENSMUSG00220028624
 protein coding gene Chr14:58729533-58746076 (-)
BALB/cJ ENSMUSG00180030191
 protein coding gene Chr14:59002197-59018697 (-)
C3H/HeJ ENSMUSG00175036234
 protein coding gene Chr14:60762848-60779388 (-)
C57BL/6NJ ENSMUSG00215020865
 protein coding gene Chr14:58939038-58955582 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019489
 protein coding gene Chr14:61689231-61705998 (-)
CAST/EiJ ENSTCUG00005038010
 protein coding gene Chr14:60644075-60660389 (-)
CBA/J ENSMUSG00210037959
 protein coding gene Chr14:59378669-59395210 (-)
DBA/2J ENSMUSG00185022145
 protein coding gene Chr14:64548249-64564794 (-)
FVB/NJ ENSMUSG00205029980
 protein coding gene Chr14:58888576-58905184 (-)
JF1/MsJ ENSUMUG00000017882
 protein coding gene Chr14:75724652-75741170 (-)
LP/J ENSMUSG00230012297
 protein coding gene Chr14:76577462-76593947 (-)
NOD/ShiLtJ ENSMUSG00190028381
 protein coding gene Chr14:59173802-59190344 (-)
NZO/HlLtJ ENSMUSG00225038388
 protein coding gene Chr14:66900610-66917149 (-)
PWK/PhJ ENSLUMG00010032475
 protein coding gene Chr14:58575633-58591936 (-)
SPRET/EiJ ENSMSPG00010023388
 protein coding gene Chr14:62137431-62153776 (-)
WSB/EiJ ENSIUOG00005035721
 protein coding gene Chr14:58616686-58633212 (-)



Homology
more
  • Human Ortholog
    FHIP2B, FHF complex subunit HOOK interacting protein 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHIP2B, FHF complex subunit HOOK interacting protein 2B
  • Synonyms
    FAI16, FAM160B2, RAI16, RAM160B2
  • Links
    NCBI Gene ID: 64760
    UniProt: Q86V87

  • Chr Location
    8p21.3; chr8:22089139-22104911 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice expressing a protein lacking exon 3 show increased susceptibility to induced colitis and colitis-associated colorectal cancer. Mice show an increase in bacailli and decrease in A. muciniphila in the microflora and exacerbated high-fat diet-induced steatohepatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022095 Ensembl Gene Model | MGI Sequence Detail 16540 C57BL/6J ±  kb
    transcript ENSMUST00000022690 Ensembl | MGI Sequence Detail 4033 Not Applicable  
    polypeptide ENSMUSP00000022690 Ensembl | MGI Sequence Detail 744 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032178 FHF complex subunit HOOK-interacting protein 2B
      (term hierarchy)
    • InterPro Domains
      IPR019384 FHF complex subunit HOOK interacting protein
      IPR045669 FHF complex subunit HOOK-interacting protein, C-terminal
      IPR045668 FHF complex subunit HOOK-interacting protein, KELAA motif
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9
    Other
    Accession IDs
    less
    MGI:6715958
    References
    more
    • Summaries
      All 30
      Gene Ontology 1
      Phenotypes 16
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory