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Drc1 Gene Detail
Summary
  • Symbol
    Drc1
  • Name
    dynein regulatory complex subunit 1
  • Synonyms
    b2b1654Clo, Ccdc164, Gm1060, LOC381738
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685906
    NCBI Gene: 381738
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30486386-30524039 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685906
 protein coding gene Chr5:30486328-30524039 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029388
 protein coding gene Chr5:28257409-28296463 (+)
A/J MGP_AJ_G0029354
 protein coding gene Chr5:27336076-27374671 (+)
AKR/J MGP_AKRJ_G0029305
 protein coding gene Chr5:28412670-28503758 (+)
BALB/cJ MGP_BALBcJ_G0029365
 protein coding gene Chr5:27863305-27901439 (+)
C3H/HeJ MGP_C3HHeJ_G0029086
 protein coding gene Chr5:28466402-28509546 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029818
 protein coding gene Chr5:29990184-30034598 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027056
 protein coding gene Chr5:24835131-24871599 (+)
CAST/EiJ MGP_CASTEiJ_G0028497
 protein coding gene Chr5:27553017-27595705 (+)
CBA/J MGP_CBAJ_G0029054
 protein coding gene Chr5:30564821-30617964 (+)
DBA/2J MGP_DBA2J_G0029203
 protein coding gene Chr5:27529261-27565454 (+)
FVB/NJ MGP_FVBNJ_G0029161
 protein coding gene Chr5:26934641-26974217 (+)
LP/J MGP_LPJ_G0029288
 protein coding gene Chr5:28711717-28757465 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029190
 protein coding gene Chr5:31483929-31524901 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029852
 protein coding gene Chr5:27979608-28020264 (+)
PWK/PhJ MGP_PWKPhJ_G0028221
 protein coding gene Chr5:26636824-26676562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028052
 protein coding gene Chr5:27316589-27352930 (+)
WSB/EiJ MGP_WSBEiJ_G0028577
 protein coding gene Chr5:28054001-28093650 (+)



Homology
more
  • Human Ortholog
    DRC1, dynein regulatory complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRC1, dynein regulatory complex subunit 1
  • Synonyms
    C2orf39, CCDC164, CILD21, SPGF80
  • Links
    NCBI Gene ID: 92749
    neXtProt AC: NX_Q96MC2
    UniProt: Q96MC2

  • Chr Location
    2p23.3; chr2:26401920-26456711 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Drc1 mouse models; 2 with human DRC1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 6 alleles in 5 genetic backgrounds
    28 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit heterotaxy with complex congenital heart disease such as transposition of the great arteries (TGA), atrioventricular septal defects (AVSD), and vein abnormalities; immotile/dyskinetic airway cilia are also seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    12
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073102 Ensembl Gene Model | MGI Sequence Detail 37654 C57BL/6J ±  kb
    transcript ENSMUST00000101448 Ensembl | MGI Sequence Detail 2471 Not Applicable  
    polypeptide ENSMUSP00000098992 Ensembl | MGI Sequence Detail 753 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031828 coiled-coil domain-containing protein 164
      (term hierarchy)
    • InterPro Domains
      IPR039750 Dynein regulatory complex protein
      IPR039505 Dynein regulatory complex protein 1/2, N-terminal
      IPR029440 Dynein regulatory complex protein 1, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5438047
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:322334 Zhang J, et al., Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse. Hum Mol Genet. 2021 Oct 13;30(21):1996-2011
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory