Lrrc37 Gene Detail

Summary

• Symbol
  Lrrc37
• Name
  leucine rich repeat containing 37
• Synonyms
  Gm884, LOC380730

• Feature Type
  protein coding gene
• IDs
  MGI:2685730
  NCBI Gene: 380730
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr11:103425403-103511966 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 67.38 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  414 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685730	protein coding gene	Chr11:103425403-103512309 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019264	protein coding gene	Chr11:106618292-106716192 (-)
A/J	MGP_AJ_G0019232	protein coding gene	Chr11:102093329-102172346 (-)
AKR/J	MGP_AKRJ_G0019201	protein coding gene	Chr11:105235574-105326147 (-)
BALB/cJ	MGP_BALBcJ_G0019206	protein coding gene	Chr11:102536448-102615402 (-)
C3H/HeJ	MGP_C3HHeJ_G0019015	protein coding gene	Chr11:105461008-105551672 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019656	protein coding gene	Chr11:109929447-110020831 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017281	protein coding gene	Chr11:99508193-99586867 (-)
CAST/EiJ	MGP_CASTEiJ_G0018569	protein coding gene	Chr11:106478480-106560790 (-)
CBA/J	MGP_CBAJ_G0018984	protein coding gene	Chr11:114495353-114589113 (-)
DBA/2J	MGP_DBA2J_G0019096	protein coding gene	Chr11:101596352-101673453 (-)
FVB/NJ	MGP_FVBNJ_G0019087	protein coding gene	Chr11:101121417-101196566 (-)
LP/J	MGP_LPJ_G0019165	protein coding gene	Chr11:107117401-107201091 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019117	protein coding gene	Chr11:113837055-113931031 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019693	protein coding gene	Chr11:105622878-105704488 (-)
PWK/PhJ	MGP_PWKPhJ_G0018333	protein coding gene	Chr11:102681992-102759634 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018124	protein coding gene	Chr11:105366968-105445214 (-)
WSB/EiJ	MGP_WSBEiJ_G0018618	protein coding gene	Chr11:105623466-105706608 (-)

Homology

• Human Ortholog
  LRRC37A, leucine rich repeat containing 37A

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LRRC37A, leucine rich repeat containing 37A
  
• Synonyms
  LRRC37, LRRC37A1
• Links
  HGNC:29069

  NCBI Gene ID: 9884

  neXtProt AC: NX_A6NMS7

  UniProt: A6NMS7

  
  
• Chr Location
  17q21.31; chr17:46248044-46338077 (+)  GRCh38

---

• Human Ortholog
  LRRC37A2, leucine rich repeat containing 37 member A2
  
• Synonyms
  LRRC37
• Links
  HGNC:32404

  NCBI Gene ID: 474170

  neXtProt AC: NX_A6NM11

  UniProt: A6NM11

  
  
• Chr Location
  chr17:46372792-47049128 (+)  GRCh38

---

• Human Ortholog
  LRRC37A3, leucine rich repeat containing 37 member A3
  
• Synonyms
  LRRC37, LRRC37A
• Links
  HGNC:32427

  NCBI Gene ID: 374819

  neXtProt AC: NX_O60309

  UniProt: O60309

  
  
• Chr Location
  17q24.1; chr17:64854130-64919480 (-)  GRCh38

---

• Human Ortholog
  LRRC37B, leucine rich repeat containing 37B
  
• Synonyms
  LRRC37
• Links
  HGNC:29070

  NCBI Gene ID: 114659

  neXtProt AC: NX_Q96QE4

  UniProt: Q96QE4

  
  
• Chr Location
  17q11.2; chr17:32007383-32053504 (+)  GRCh38

---

• Alliance of Genome Resources
  Lrrc37 stringent orthology
  4 human;1 mouse
  
• HCOP
  vertebrate homology predictions: LRRC37A, LRRC37A2, LRRC37A3, LRRC37B
• Gene Tree
  Lrrc37
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  2
• Gene trapped
  1
• Targeted
  1
• Genomic Mutations
  1 involving Lrrc37
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  58 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Lrrc37 interacts with 52 markers (Mir1b, Mir7-1, Mir19a, ...) View All

Sequences &
Gene Models

• All Sequences
  55
• RefSeq
  5
• UniProt
  3
• CCDS
  CCDS48952.1

• Ensembl
  ENSMUSG00000034239 (Evidence)
• NCBI Gene
  380730

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000034239	Ensembl Gene Model | MGI Sequence Detail	86564	C57BL/6J
transcript	ENSMUST00000059279	Ensembl | MGI Sequence Detail	10977	Not Applicable
polypeptide	ENSMUSP00000058511	Ensembl | MGI Sequence Detail	3643	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR001611 Leucine-rich repeat
  IPR015753 Leucine-rich repeat-containing protein 37
  IPR032754 Leucine-rich repeat-containing protein 37, N-terminal
  IPR032675 Leucine-rich repeat domain superfamily
  IPR003591 Leucine-rich repeat, typical subtype
  IPR029423 LRRC37A/B like protein 1, C-terminal

Molecular
Reagents

• All nucleic 2

  cDNA 2

  
  

  Microarray probesets 2

References

• Summaries
  All 21

  Phenotypes 7
• Earliest
  J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
• Latest
  J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

TSS for Lrrc37:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111203	Chr11:103512248-103512268 (-)	-292 bp
Tssr3691	Chr11:103512239-103512242 (-)	-275 bp
Tssr111202	Chr11:103458706-103458707 (-)	53,259 bp