Mir195a MGI Mouse Gene Detail - MGI:2676859

Symbol

Mir195a
Name

microRNA 195a
Synonyms

Mirn195, mmu-mir-195, mmu-mir-195a

Feature Type

miRNA gene
IDs

MGI:2676859
NCBI Gene: 387190
Member of

Mirc27 cluster
Alliance

genome feature page

Sequence Map

Chr11:70125868-70125961 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

1 experiment

SNPs within 2kb

34 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676859	miRNA gene	Chr11:70125868-70125961 (+)
129S1/SvImJ	ENSMUSG00200050195	miRNA gene	Chr11:67072895-67072988 (+)
A/J	ENSMUSG00195053151	miRNA gene	Chr11:67099382-67099475 (+)
AKR/J	ENSMUSG00220054234	miRNA gene	Chr11:67208364-67208457 (+)
BALB/cJ	ENSMUSG00180053873	miRNA gene	Chr11:67167933-67168026 (+)
C3H/HeJ	ENSMUSG00175054531	miRNA gene	Chr11:67118154-67118247 (+)
C57BL/6NJ	ENSMUSG00215055030	miRNA gene	Chr11:66895290-66895383 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007127	miRNA gene	Chr11:64985421-64985514 (+)
CAST/EiJ	ENSTCUG00005053740	miRNA gene	Chr11:66659769-66659862 (+)
CBA/J	ENSMUSG00210054379	miRNA gene	Chr11:66972204-66972297 (+)
DBA/2J	ENSMUSG00185056831	miRNA gene	Chr11:67172454-67172547 (+)
FVB/NJ	ENSMUSG00205053937	miRNA gene	Chr11:67064182-67064275 (+)
JF1/MsJ	ENSUMUG00000057036	miRNA gene	Chr11:67570952-67571045 (+)
LP/J	ENSMUSG00230053858	miRNA gene	Chr11:68283216-68283309 (+)
NOD/ShiLtJ	ENSMUSG00190054186	miRNA gene	Chr11:67202113-67202206 (+)
NZO/HlLtJ	ENSMUSG00225048245	miRNA gene	Chr11:70464667-70464760 (+)
PWK/PhJ	ENSLUMG00010053693	miRNA gene	Chr11:67082339-67082432 (+)
SPRET/EiJ	ENSMSPG00010049501	miRNA gene	Chr11:67804545-67804638 (+)
WSB/EiJ	ENSIUOG00005052655	miRNA gene	Chr11:67097031-67097124 (+)

Human Ortholog

MIR195, microRNA 195

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR195, microRNA 195
Synonyms

mir-195, MIRN195, miRNA195
Links

HGNC:31566

NCBI Gene ID: 406971
Chr Location

chr17:7017615-7017701 (-) GRCh38

MGI Vertebrate Homology

Mir195a stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR195
Gene Tree

Mir195a

Diseases

1 with human MIR195 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

2 involving Mir195a
Find Mice (IMSR)

3 strains or lines available

Homozygous inactivation of this gene results in increased blood-brain barrier permeability.

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

616
Tissues

12
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

25
RefSeq

1

Ensembl

ENSMUSG00000065411 (Evidence)
NCBI Gene

387190

Representative Sequences				Length	Strain/Species	Flank
	genomic	387190	NCBI Gene Model \| MGI Sequence Detail	94	C57BL/6J	± kb
	transcript	NR_029581	RefSeq \| MGI Sequence Detail	94	C57BL/6

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All nucleic 5

Primer pair 3

Other 2

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miRBase

MI0000237

Summaries

All 54

Developmental Gene Expression 11

Gene Ontology 7

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361665 Ding Z, et al., DEmiRNA-mRNA regulatory network reveals miR-122-5p as a regulatory factor of arginine metabolism in necrotizing enterocolitis. Front Genet. 2024;15:1480431

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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