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Adamts15 Gene Detail
Summary
  • Symbol
    Adamts15
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449569
    NCBI Gene: 235130
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:30810451-30833748 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449569
 protein coding gene Chr9:30810451-30833853 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034513
 protein coding gene Chr9:28535527-28558761 (-)
A/J MGP_AJ_G0034491
 protein coding gene Chr9:27853714-27876946 (-)
AKR/J MGP_AKRJ_G0034417
 protein coding gene Chr9:28415740-28439053 (-)
BALB/cJ MGP_BALBcJ_G0034482
 protein coding gene Chr9:27730806-27754049 (-)
C3H/HeJ MGP_C3HHeJ_G0034194
 protein coding gene Chr9:28775999-28799234 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035003
 protein coding gene Chr9:29528885-29552110 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031933
 protein coding gene Chr9:26685183-26708747 (-)
CAST/EiJ MGP_CASTEiJ_G0033517
 protein coding gene Chr9:28623952-28650395 (-)
CBA/J MGP_CBAJ_G0034168
 protein coding gene Chr9:30501839-30525196 (-)
DBA/2J MGP_DBA2J_G0034325
 protein coding gene Chr9:27867960-27891966 (-)
FVB/NJ MGP_FVBNJ_G0034268
 protein coding gene Chr9:27277825-27301055 (-)
LP/J MGP_LPJ_G0034411
 protein coding gene Chr9:28737825-28761111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034312
 protein coding gene Chr9:32174470-32201842 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035023
 protein coding gene Chr9:28417645-28440921 (-)
PWK/PhJ MGP_PWKPhJ_G0033222
 protein coding gene Chr9:27801300-27824687 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033056
 protein coding gene Chr9:28501344-28524950 (-)
WSB/EiJ MGP_WSBEiJ_G0033632
 protein coding gene Chr9:28155794-28179131 (-)



Homology
more
  • Human Ortholog
    ADAMTS15, ADAM metallopeptidase with thrombospondin type 1 motif 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS15, ADAM metallopeptidase with thrombospondin type 1 motif 15
  • Synonyms
    DA12
  • Links
    NCBI Gene ID: 170689
    neXtProt AC: NX_Q8TE58
    UniProt: Q8TE58

  • Chr Location
    11q24.3; chr11:130448645-130476645 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADAMTS15 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    960
  • Tissues
    95
  • cDNA Data
    45
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033453 Ensembl Gene Model | MGI Sequence Detail 23298 C57BL/6J ±  kb
    transcript ENSMUST00000065112 Ensembl | MGI Sequence Detail 5928 Not Applicable  
    polypeptide ENSMUSP00000067022 Ensembl | MGI Sequence Detail 950 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 45
      Primer pair 4
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:139177 Hoffman BG, et al., Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
    • Latest
      J:338614 Boschann F, et al., Biallelic variants in ADAMTS15 cause a novel form of distal arthrogryposis. Genet Med. 2022 Oct;24(10):2187-2193
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory