Prss50 MGI Mouse Gene Detail - MGI:2447303

Symbol

Prss50
Name

serine protease 50
Synonyms

Tsp50

Feature Type

protein coding gene
IDs

MGI:2447303
NCBI Gene: 235631
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:110687035-110693697 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 60.79 cM
Mapping Data

2 experiments

SNPs within 2kb

293 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447303	protein coding gene	Chr9:110687032-110693697 (+)
129S1/SvImJ	ENSMUSG00200041620	protein coding gene	Chr9:107780411-107787030 (+)
A/J	ENSMUSG00195034207	protein coding gene	Chr9:107073950-107080578 (+)
AKR/J	ENSMUSG00220027906	protein coding gene	Chr9:107409592-107416216 (+)
BALB/cJ	ENSMUSG00180028417	protein coding gene	Chr9:107528830-107535455 (+)
C3H/HeJ	ENSMUSG00175031694	protein coding gene	Chr9:107744633-107751266 (+)
C57BL/6NJ	ENSMUSG00215020550	protein coding gene	Chr9:107624760-107631417 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032745	protein coding gene	Chr9:106140986-106148010 (+)
CAST/EiJ	ENSTCUG00005028715	protein coding gene	Chr9:107436340-107443120 (+)
CBA/J	ENSMUSG00210027468	protein coding gene	Chr9:107470446-107477139 (+)
DBA/2J	ENSMUSG00185033600	protein coding gene	Chr9:107792580-107799204 (+)
FVB/NJ	ENSMUSG00205026455	protein coding gene	Chr9:107740296-107746978 (+)
JF1/MsJ	ENSUMUG00000025113	protein coding gene	Chr9:107571351-107578060 (+)
LP/J	ENSMUSG00230043172	protein coding gene	Chr9:107912522-107919146 (+)
NOD/ShiLtJ	ENSMUSG00190048705	protein coding gene	Chr9:107380247-107386871 (+)
NZO/HlLtJ	ENSMUSG00225023067	protein coding gene	Chr9:108170996-108177620 (+)
PWK/PhJ	ENSLUMG00010036757	protein coding gene	Chr9:107578959-107585675 (+)
SPRET/EiJ	ENSMSPG00010044760	protein coding gene	Chr9:109365361-109372064 (+)
WSB/EiJ	ENSIUOG00005038003	protein coding gene	Chr9:106834065-106840716 (+)

Human Ortholog

PRSS50, serine protease 50

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRSS50, serine protease 50
Synonyms

CT20, TSP50
Links

HGNC:17910

NCBI Gene ID: 29122

UniProt: Q9UI38
Chr Location

3p21.31; chr3:46712117-46717869 (-) GRCh38

MGI Vertebrate Homology

Prss50 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRSS50
Gene Tree

Prss50

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Gene trapped

3
Spontaneous

1
Targeted

4
Genomic Mutations

1 involving Prss50
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased male fertility with reduced litter sizes and teratozoospermia with reduced sperm motility and abnormal sperm heads and tails.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

618
Tissues

16
cDNA Data

5
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS23577.1

Ensembl

ENSMUSG00000048752 (Evidence)
NCBI Gene

235631

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048752	Ensembl Gene Model \| MGI Sequence Detail	6663	C57BL/6J	± kb
transcript	ENSMUST00000051097	Ensembl \| MGI Sequence Detail	1456	Not Applicable
polypeptide	ENSMUSP00000059668	Ensembl \| MGI Sequence Detail	439	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016734 testis-specific protease-like protein 50

(term hierarchy)
EC

3.4.25.-
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR050127 Serine Proteases (Peptidase S1 Family)

IPR001254 Serine proteases, trypsin domain
GlyGen

Q8BLH5 3 sites, 1 N-linked glycan (1 site)

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All nucleic 7

cDNA 5

Primer pair 2

Antibodies 1

Microarray probesets 1

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 18
Earliest

J:13132 DEOL MS, et al., The spinner mouse. J Hered. 1962 May-Jun;53:133-6
Latest

J:386576 George SS, et al., Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment. Adv Sci (Weinh). 2026 Feb;13(7):e08268

TSS for Prss50:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87425	Chr9:110686996-110687006 (+)	-34 bp
Tssr87426	Chr9:110687026-110687055 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24