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Flvcr1 Gene Detail
Summary
  • Symbol
    Flvcr1
  • Name
    feline leukemia virus subgroup C cellular receptor 1
  • Synonyms
    9630055N22Rik, Mfsd7b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444881
    NCBI Gene: 226844
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190738044-190758355 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    575 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444881
 protein coding gene Chr1:190738029-190758387 (-)
129S1/SvImJ ENSMUSG00200003410
 protein coding gene Chr1:188511396-188538164 (-)
A/J ENSMUSG00195007966
 protein coding gene Chr1:188080139-188118049 (-)
AKR/J ENSMUSG00220004461
 protein coding gene Chr1:187337035-187361905 (-)
BALB/cJ ENSMUSG00180016164
 protein coding gene Chr1:188145575-188183482 (-)
C3H/HeJ ENSMUSG00175021934
 protein coding gene Chr1:188333587-188371497 (-)
C57BL/6NJ ENSMUSG00215011809
 protein coding gene Chr1:187565964-187590904 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015042
 protein coding gene Chr1:180809915-180830596 (-)
CAST/EiJ ENSTCUG00005001855
 protein coding gene Chr1:186109127-186164676 (-)
CBA/J ENSMUSG00210003311
 protein coding gene Chr1:188006477-188033245 (-)
DBA/2J ENSMUSG00185010416
 protein coding gene Chr1:192619729-192646497 (-)
FVB/NJ ENSMUSG00205003910
 protein coding gene Chr1:187004622-187029528 (-)
JF1/MsJ ENSUMUG00000005500
 protein coding gene Chr1:191593747-191631597 (-)
LP/J ENSMUSG00230021035
 protein coding gene Chr1:192144478-192182387 (-)
NOD/ShiLtJ ENSMUSG00190026796
 protein coding gene Chr1:187978881-188016775 (-)
NZO/HlLtJ ENSMUSG00225015322
 protein coding gene Chr1:195916659-195943427 (-)
PWK/PhJ ENSLUMG00010006213
 protein coding gene Chr1:186827572-186865468 (-)
SPRET/EiJ ENSMSPG00010022488
 protein coding gene Chr1:190383202-190404481 (-)
WSB/EiJ ENSIUOG00005004339
 protein coding gene Chr1:187342029-187367408 (-)



Homology
more
  • Human Ortholog
    FLVCR1, FLVCR choline and heme transporter 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLVCR1, FLVCR choline and heme transporter 1
  • Synonyms
    AXPC1, FLVCR, MFSD7B, NEDMISH, PCA, PCARP, RETSNS, SLC49A1
  • Links
    NCBI Gene ID: 28982
    UniProt: Q9Y5Y0

  • Chr Location
    1q32.3; chr1:212858237-212899363 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Flvcr1 mouse models; 2 with human FLVCR1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit runting, cardiomegaly and splenomegaly, lack definitive erythropoiesis, develop severe hyperchromic macrocytic anemia and reticulocytopenia, and show craniofacial and limb defects and intrauterine lethality modulated by genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    21
  • cDNA Data
    39
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066595 Ensembl Gene Model | MGI Sequence Detail 20312 C57BL/6J ±  kb
    transcript ENSMUST00000085635 Ensembl | MGI Sequence Detail 4040 Not Applicable  
    polypeptide ENSMUSP00000082777 Ensembl | MGI Sequence Detail 560 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 39
      Primer pair 10
      Other 1
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:5906162
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:370513 Kumar A, et al., Iron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2318420121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory