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Tmem117 Gene Detail
Summary
  • Symbol
    Tmem117
  • Name
    transmembrane protein 117
  • Synonyms
    B930062P21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444580
    NCBI Gene: 320709
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:94527113-94993979 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 48.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15040 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444580
protein coding gene Chr15:94527066-94993979 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022262
protein coding gene Chr15:96096819-96589349 (+)
A/J MGP_AJ_G0022221
protein coding gene Chr15:92356704-92834625 (+)
AKR/J MGP_AKRJ_G0022196
protein coding gene Chr15:95146099-95633101 (+)
BALB/cJ MGP_BALBcJ_G0022227
protein coding gene Chr15:92522427-93003209 (+)
C3H/HeJ MGP_C3HHeJ_G0021997
protein coding gene Chr15:95163287-95650602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022672
protein coding gene Chr15:99648220-100159369 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020198
protein coding gene Chr15:88383990-88844527 (+)
CAST/EiJ MGP_CASTEiJ_G0021519
protein coding gene Chr15:95986283-96489302 (+)
CBA/J MGP_CBAJ_G0021964
protein coding gene Chr15:102971654-103500758 (+)
DBA/2J MGP_DBA2J_G0022091
protein coding gene Chr15:91803876-92277240 (+)
FVB/NJ MGP_FVBNJ_G0022070
protein coding gene Chr15:90808833-91281741 (+)
LP/J MGP_LPJ_G0022162
protein coding gene Chr15:96221285-96718278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022090
protein coding gene Chr15:107262673-107788309 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022687
protein coding gene Chr15:95228777-95717131 (+)
PWK/PhJ MGP_PWKPhJ_G0021260
protein coding gene Chr15:91861280-92338413 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021094
protein coding gene Chr15:94974969-95484014 (+)
WSB/EiJ MGP_WSBEiJ_G0021568
protein coding gene Chr15:95735751-96216926 (+)



Homology
more
  • Human Ortholog
    TMEM117, transmembrane protein 117
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM117, transmembrane protein 117
  • Links
    NCBI Gene ID: 84216
    neXtProt AC: NX_Q9H0C3
    UniProt: Q9H0C3

  • Chr Location
    12q12; chr12:43795802-44399108 (+)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with loss of expression in the posterior pituitary display loss of vassopressin neurons and transient increases in hypoglycemia induced glucagon secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063296 Ensembl Gene Model | MGI Sequence Detail 466867 C57BL/6J ±  kb
    transcript ENSMUST00000080141 Ensembl | MGI Sequence Detail 2717 Not Applicable  
    polypeptide ENSMUSP00000079038 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Diseases 1
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:341551 Yang Y, et al., Transmembrane protein 117 knockdown protects against angiotensin-II-induced cardiac hypertrophy. Hypertens Res. 2023 Oct;46(10):2326-2339

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/24/2024
    MGI 6.24
    The Jackson Laboratory