Pde8b MGI Mouse Gene Detail - MGI:2443999

Symbol

Pde8b
Name

phosphodiesterase 8B
Synonyms

B230331L10Rik, C030047E14Rik

Feature Type

protein coding gene
IDs

MGI:2443999
NCBI Gene: 218461
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:95160962-95386844 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 49.22 cM
Mapping Data

2 experiments

SNPs within 2kb

1465 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443999	protein coding gene	Chr13:95160962-95386904 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020837	protein coding gene	Chr13:96468898-96704109 (-)
A/J	MGP_AJ_G0020791	protein coding gene	Chr13:92853468-93078553 (-)
AKR/J	MGP_AKRJ_G0020765	protein coding gene	Chr13:95690163-95917991 (-)
BALB/cJ	MGP_BALBcJ_G0020788	protein coding gene	Chr13:93533821-93761575 (-)
C3H/HeJ	MGP_C3HHeJ_G0020581	protein coding gene	Chr13:95385396-95623965 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021224	protein coding gene	Chr13:99397280-99640115 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018793	protein coding gene	Chr13:88690280-88915267 (-)
CAST/EiJ	MGP_CASTEiJ_G0020100	protein coding gene	Chr13:94661250-94913323 (-)
CBA/J	MGP_CBAJ_G0020540	protein coding gene	Chr13:103347673-103602816 (-)
DBA/2J	MGP_DBA2J_G0020665	protein coding gene	Chr13:92639210-92866418 (-)
FVB/NJ	MGP_FVBNJ_G0020646	protein coding gene	Chr13:91425944-91650867 (-)
LP/J	MGP_LPJ_G0020740	protein coding gene	Chr13:96573579-96825733 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020674	protein coding gene	Chr13:103796792-104053358 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021264	protein coding gene	Chr13:95090405-95323241 (-)
PWK/PhJ	MGP_PWKPhJ_G0019852	protein coding gene	Chr13:91369776-91618048 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019676	protein coding gene	Chr13:91373189-91610106 (-)
WSB/EiJ	MGP_WSBEiJ_G0020157	protein coding gene	Chr13:95587357-95824238 (-)

Human Ortholog

PDE8B, phosphodiesterase 8B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE8B, phosphodiesterase 8B
Synonyms

ADSD, PPNAD3
Links

HGNC:8794

NCBI Gene ID: 8622

neXtProt AC: NX_O95263

UniProt: O95263
Chr Location

5q13.3; chr5:77086715-77428256 (+) GRCh38

Alliance of Genome Resources

Pde8b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE8B
Gene Tree

Pde8b

Diseases

1 with human PDE8B associations

				Human Disease	Mouse Models
				primary pigmented nodular adrenocortical disease IDs primary pigmented nodular adrenocortical disease DOID:0060280 MESH:C566469 MESH:C566472 OMIM:610475 OMIM:610489 OMIM:614190 OMIM:615830 ORDO:189439 UMLS_CUI:C1864846 UMLS_CUI:C1864851

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Pde8b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

936
Tissues

163
cDNA Data

33
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pde8b

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Pde8b interacts with 254 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

144
RefSeq

62
UniProt

16
CCDS

CCDS49331.1, CCDS49332.1, CCDS84052.1

Ensembl

ENSMUSG00000021684 (Evidence)
NCBI Gene

218461

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021684	Ensembl Gene Model \| MGI Sequence Detail	225883	C57BL/6J	± kb
transcript	ENSMUST00000067082	Ensembl \| MGI Sequence Detail	2598	Not Applicable
polypeptide	ENSMUSP00000070465	Ensembl \| MGI Sequence Detail	865	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000012487 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

(term hierarchy)
EC

3.1.4.-, 3.1.4.53
InterPro Domains

IPR023088 3'5'-cyclic nucleotide phosphodiesterase

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR013938 3'5'-cyclic nucleotide phosphodiesterase PDE8

IPR011006 CheY-like superfamily

IPR003607 HD/PDEase domain

IPR000014 PAS domain

IPR035965 PAS domain superfamily

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All nucleic 33

cDNA 33

Microarray probesets 5

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MGI:1924861

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:302971 Leal LF, et al., Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation. Mol Cell Endocrinol. 2021 Feb 15;522:111117

TSS for Pde8b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123507	Chr13:95386776-95386839 (-)	36 bp
Tssr123502	Chr13:95302151-95302154 (-)	84,691 bp
Tssr123501	Chr13:95195606-95195624 (-)	191,229 bp
Tssr123500	Chr13:95189506-95189510 (-)	197,336 bp
Tssr123499	Chr13:95187074-95187077 (-)	199,768 bp
Tssr123498	Chr13:95185912-95185924 (-)	200,926 bp
Tssr123497	Chr13:95174832-95174840 (-)	212,008 bp
Tssr123496	Chr13:95170797-95170824 (-)	216,033 bp
Tssr123495	Chr13:95170755-95170796 (-)	216,068 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/28/2023 MGI 6.22