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Slc4a7 Gene Detail
Summary
  • Symbol
    Slc4a7
  • Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 7
  • Synonyms
    E430014N10Rik, NBC3, NBCn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443878
    NCBI Gene: 218756
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:7669819-7766808 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    659 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443878
 protein coding gene Chr14:7669819-7767484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021011
 protein coding gene Chr14:7246052-7354076 (+)
A/J MGP_AJ_G0020959
 protein coding gene Chr14:7057142-7155361 (+)
AKR/J MGP_AKRJ_G0020936
 protein coding gene Chr14:7203554-7312673 (+)
BALB/cJ MGP_BALBcJ_G0020962
 protein coding gene Chr14:7092800-7197687 (+)
C3H/HeJ MGP_C3HHeJ_G0020746
 protein coding gene Chr14:7296317-7405642 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021395
 protein coding gene Chr14:7448532-7557122 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018964
 protein coding gene Chr14:7737768-7829046 (+)
CAST/EiJ MGP_CASTEiJ_G0020269
 protein coding gene Chr14:7229795-7332767 (+)
CBA/J MGP_CBAJ_G0020712
 protein coding gene Chr14:7732976-7848700 (+)
DBA/2J MGP_DBA2J_G0020836
 protein coding gene Chr14:6979414-7080687 (+)
FVB/NJ MGP_FVBNJ_G0020818
 protein coding gene Chr14:6896916-6994398 (+)
LP/J MGP_LPJ_G0020911
 protein coding gene Chr14:7274642-7380998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020844
 protein coding gene Chr14:7785258-7893887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021428
 protein coding gene Chr14:7123938-7225223 (+)
PWK/PhJ MGP_PWKPhJ_G0020020
 protein coding gene Chr14:6994559-7094515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019840
 protein coding gene Chr14:7280068-7380357 (+)
WSB/EiJ MGP_WSBEiJ_G0020326
 protein coding gene Chr14:7171649-7261617 (+)



Homology
more
  • Human Ortholog
    SLC4A7, solute carrier family 4 member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A7, solute carrier family 4 member 7
  • Synonyms
    NBC2, NBC3, NBCN1, SBC2, SLC4A6
  • Links
    NCBI Gene ID: 9497
    neXtProt AC: NX_Q9Y6M7
    UniProt: Q9Y6M7

  • Chr Location
    3p24.1; chr3:27372723-27484420 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc4a7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption at this locus display defects of the auditory and visual systems similar to those observed in patients with Ushers syndrome. Mice homozygous for a gene trap allele exhibit disruption in sodium/bicarbonate function that impacts vasodilation and hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    4
  • cDNA Data
    97
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218756 NCBI Gene Model | MGI Sequence Detail 96990 C57BL/6J ±  kb
    transcript NM_001360504 RefSeq | MGI Sequence Detail 7777 C57BL/6  
    polypeptide Q8BTY2 UniProt | EBI | MGI Sequence Detail 1034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 97
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:5049862
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:307106 Choi I, et al., Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice. Behav Brain Res. 2021 Mar 5;401:113065
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory