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Cpeb2 Gene Detail
Summary
  • Symbol
    Cpeb2
  • Name
    cytoplasmic polyadenylation element binding protein 2
  • Synonyms
    A630055H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442640
    NCBI Gene: 231207
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:43390513-43447067 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 23.65 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1446 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442640
 protein coding gene Chr5:43382692-43447067 (+)
129S1/SvImJ ENSMUSG00200031790
 protein coding gene Chr5:38881435-38937982 (+)
A/J ENSMUSG00195028875
 protein coding gene Chr5:38286788-38343342 (+)
AKR/J ENSMUSG00220002373
 protein coding gene Chr5:38323523-38380078 (+)
BALB/cJ ENSMUSG00180021279
 protein coding gene Chr5:38111328-38167896 (+)
C3H/HeJ ENSMUSG00175018710
 protein coding gene Chr5:40082506-40139067 (+)
C57BL/6NJ ENSMUSG00215004966
 protein coding gene Chr5:38841255-38897808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027191
 protein coding gene Chr5:37674896-37731536 (+)
CAST/EiJ ENSTCUG00005023105
 protein coding gene Chr5:38199511-38256049 (+)
CBA/J ENSMUSG00210004218
 protein coding gene Chr5:39047579-39104137 (+)
DBA/2J ENSMUSG00185001315
 protein coding gene Chr5:40930057-40986665 (+)
FVB/NJ ENSMUSG00205017197
 protein coding gene Chr5:37846780-37903394 (+)
JF1/MsJ ENSUMUG00000001135
 protein coding gene Chr5:45509344-45565721 (+)
LP/J ENSMUSG00230002505
 protein coding gene Chr5:45581406-45637959 (+)
NOD/ShiLtJ ENSMUSG00190003201
 protein coding gene Chr5:38122358-38178914 (+)
NZO/HlLtJ ENSMUSG00225015253
 protein coding gene Chr5:50738429-50794920 (+)
PWK/PhJ ENSLUMG00010022490
 protein coding gene Chr5:38167310-38222342 (+)
SPRET/EiJ ENSMSPG00010029950
 protein coding gene Chr5:39437192-39494148 (+)
WSB/EiJ ENSIUOG00005016311
 protein coding gene Chr5:41007178-41063651 (+)



Homology
more
  • Human Ortholog
    CPEB2, cytoplasmic polyadenylation element binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPEB2, cytoplasmic polyadenylation element binding protein 2
  • Synonyms
    CPEB-2, CPE-BP2, hCPEB-2
  • Links
    NCBI Gene ID: 132864
    UniProt: Q7Z5Q1

  • Chr Location
    4p15.32; chr4:15002481-15070153 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early postnatal lethality, decreased heart rate, and increased parasympathetic signaling leading to increased pulmonary acetylcholine level, bronchoconstriction, severe apnea, and abnormal breathing patterns.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    24
  • cDNA Data
    34
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039782 Ensembl Gene Model | MGI Sequence Detail 56555 C57BL/6J ±  kb
    transcript ENSMUST00000166713 Ensembl | MGI Sequence Detail 7139 Not Applicable  
    polypeptide ENSMUSP00000130921 Ensembl | MGI Sequence Detail 1022 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005806 cytoplasmic polyadenylation element-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q812E0 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:365475 Duot M, et al., Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory