Trub2 MGI Mouse Gene Detail - MGI:2442186 - TruB pseudouridine (psi) synthase family member 2

Symbol

Trub2
Name

TruB pseudouridine (psi) synthase family member 2
Synonyms

G430055L02Rik

Feature Type

protein coding gene
IDs

MGI:2442186
NCBI Gene: 227682
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:29651235-29677697 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 20.57 cM
Mapping Data

1 experiment

SNPs within 2kb

699 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442186	protein coding gene	Chr2:29651235-29678514 (-)
129S1/SvImJ	ENSMUSG00200047667	protein coding gene	Chr2:26621151-26648622 (-)
A/J	ENSMUSG00195037850	protein coding gene	Chr2:26715009-26742289 (-)
AKR/J	ENSMUSG00220049333	protein coding gene	Chr2:26833548-26860828 (-)
BALB/cJ	ENSMUSG00180051450	protein coding gene	Chr2:26734295-26761578 (-)
C3H/HeJ	ENSMUSG00175051971	protein coding gene	Chr2:26703616-26730897 (-)
C57BL/6NJ	ENSMUSG00215048718	protein coding gene	Chr2:26769288-26796568 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023368	protein coding gene	Chr2:25620808-25649459 (-)
CAST/EiJ	ENSTCUG00005052577	protein coding gene	Chr2:26439827-26467014 (-)
CBA/J	ENSMUSG00210016555	protein coding gene	Chr2:26736775-26764055 (-)
DBA/2J	ENSMUSG00185045999	protein coding gene	Chr2:26629090-26656368 (-)
FVB/NJ	ENSMUSG00205043981	protein coding gene	Chr2:26481116-26508394 (-)
JF1/MsJ	ENSUMUG00000020804	protein coding gene	Chr2:26525394-26552734 (-)
LP/J	ENSMUSG00230036267	protein coding gene	Chr2:28556923-28584396 (-)
NOD/ShiLtJ	ENSMUSG00190038289	protein coding gene	Chr2:26735936-26763212 (-)
NZO/HlLtJ	ENSMUSG00225007275	protein coding gene	Chr2:36305782-36333438 (-)
PWK/PhJ	ENSLUMG00010042581	protein coding gene	Chr2:26602369-26629894 (-)
SPRET/EiJ	ENSMSPG00010042519	protein coding gene	Chr2:27326732-27352829 (-)
WSB/EiJ	ENSIUOG00005050338	protein coding gene	Chr2:26587640-26615113 (-)

Human Ortholog

TRUB2, TruB pseudouridine synthase family member 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRUB2, TruB pseudouridine synthase family member 2
Synonyms

CLONE24922
Links

HGNC:17170

NCBI Gene ID: 26995

UniProt: O95900
Chr Location

9q34.11; chr9:128305159-128322741 (-) GRCh38

MGI Vertebrate Homology

Trub2 stringent orthology
1 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRUB2
Gene Tree

Trub2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

6
Targeted

3
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal trophoblast layer formation and complete embryonic lethality during organogenesis.

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All GO Annotations

35
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

600
Tissues

2
cDNA Data

59
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trub2

ZFIN trub2

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All Sequences

69
RefSeq

11
UniProt

4
CCDS

CCDS15856.1, CCDS71016.1

Ensembl

ENSMUSG00000039826 (Evidence)
NCBI Gene

227682

			Length	Strain/Species	Flank
genomic	227682	NCBI Gene Model \| MGI Sequence Detail	26463	C57BL/6J	± kb
transcript	NM_145520	RefSeq \| MGI Sequence Detail	4003	Not Specified
polypeptide	Q91WG3	UniProt \| EBI \| MGI Sequence Detail	331	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032351 pseudouridylate synthase TRUB2, mitochondrial

(term hierarchy)
EC

5.4.99.-, 5.4.99.25
InterPro Domains

IPR039048 Mitochondrial pseudouridylate synthase Trub2

IPR020103 Pseudouridine synthase, catalytic domain superfamily

IPR002501 Pseudouridine synthase II, N-terminal

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All nucleic 60

cDNA 59

Primer pair 1

Microarray probesets 6

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:363164 Zhu S, et al., Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the mouse craniofacial development. iScience. 2025 Mar 21;28(3):111972

TSS for Trub2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr451	Chr2:29678132-29678152 (-)	-445 bp
Tssr23335	Chr2:29677640-29677692 (-)	31 bp
Tssr23334	Chr2:29677262-29677266 (-)	433 bp
Tssr23333	Chr2:29663519-29663529 (-)	14,173 bp
Tssr23332	Chr2:29662265-29662276 (-)	15,426 bp
Tssr23331	Chr2:29662234-29662245 (-)	15,457 bp
Tssr449	Chr2:29662212-29662216 (-)	15,483 bp
Tssr23330	Chr2:29662203-29662208 (-)	15,491 bp
Tssr23329	Chr2:29662175-29662184 (-)	15,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24