About   Help   FAQ
Cyp2d34 Gene Detail
Summary
  • Symbol
    Cyp2d34
  • Name
    cytochrome P450, family 2, subfamily d, polypeptide 34
  • Synonyms
    MGC:18824
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385022
    NCBI Gene: 223706
  • Member of
    Cyp2d cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:82500166-82505147 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385022
 protein coding gene Chr15:82500164-82505157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022151
 protein coding gene Chr15:83228157-83233041 (-)
A/J MGP_AJ_G0022110
 protein coding gene Chr15:80194772-80199717 (-)
AKR/J MGP_AKRJ_G0022084
 protein coding gene Chr15:82499094-82504016 (-)
BALB/cJ MGP_BALBcJ_G0022116
 protein coding gene Chr15:80321199-80326177 (-)
C3H/HeJ MGP_C3HHeJ_G0021886
 protein coding gene Chr15:82503677-82513388 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022560
 protein coding gene Chr15:86461004-86466251 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0021407
 protein coding gene Chr15:83208056-83212965 (-)
CBA/J MGP_CBAJ_G0021852
 protein coding gene Chr15:89190081-89195430 (-)
DBA/2J MGP_DBA2J_G0021979
 protein coding gene Chr15:79708935-79713909 (-)
FVB/NJ MGP_FVBNJ_G0021957
 protein coding gene Chr15:78520518-78530162 (-)
LP/J MGP_LPJ_G0022050
 protein coding gene Chr15:83381595-83386522 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0022575
 protein coding gene Chr15:82545451-82550397 (-)
PWK/PhJ MGP_PWKPhJ_G0021146
 protein coding gene Chr15:79556316-79559955 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021456
 protein coding gene Chr15:82986242-82992331 (-)



Homology
more
  • Human Ortholog
    CYP2D6, cytochrome P450 family 2 subfamily D member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2D6, cytochrome P450 family 2 subfamily D member 6
  • Synonyms
    CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450C2D, P450DB1, P450-DB1
  • Links
    NCBI Gene ID: 1565
    neXtProt AC: NX_P10635
    UniProt: P10635

  • Chr Location
    22q13.2; chr22:42126499-42130865 (-)  GRCh38
  • Human Ortholog
    CYP2D7, cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
  • Synonyms
    CYP2D, CYP2D@, CYP2D6, CYP2D7AP, CYP2D7P, CYP2D7P1, P450C2D, P450DB1, RNA40057
  • Links
    NCBI Gene ID: 1564
    neXtProt AC: NX_A0A087X1C5
    UniProt: A0A087X1C5

  • Chr Location
    22q13.2; chr22:42139576-42149455 (-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human CYP2D6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000094559 Ensembl Gene Model | MGI Sequence Detail 4982 C57BL/6J ±  kb
transcript ENSMUST00000109515 Ensembl | MGI Sequence Detail 1660 Not Applicable  
polypeptide ENSMUSP00000105141 Ensembl | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Diseases 1
    Gene Ontology 3
    Phenotypes 24
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:286122 Henderson CJ, et al., An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metab Dispos. 2019 Jun;47(6):601-615
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory